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目的探讨垂体生长激素腺瘤合并结直肠癌的临床特征。方法回顾分析2006—2011年收治的8例垂体生长激素腺瘤合并结直肠癌的临床和病理资料。结果男6例,女2例;中位年龄59岁(48～69岁)。有垂体瘤肢端肥大病史10～30年,2例已行垂体瘤治疗。术前检测激素水平和MRI及CT影像学检查。经纤维结肠镜活检确定为结直肠癌。所有患者均按结直肠癌行手术治疗。分期为Dukes B,C期。术后均辅以化疗。术后并发症有肺部感染,高血压,高血糖,低钾血症等,均经对症处理好转,无吻合口瘘、腹腔感染等并发症;1例自动出院(后失访)。7例随访2～44个月,均健在。结论对垂体生长激素腺瘤合并结直肠癌患者,应先按结直肠癌进行综合治疗,视情况处理垂体腺瘤。
Objective To investigate the clinical features of pituitary growth hormone adenoma with colorectal cancer. Methods Retrospective analysis of clinical and pathological data of 8 cases of pituitary growth hormone adenoma combined with colorectal cancer admitted from 2006 to 2011. Results 6 males and 2 females; median age of 59 years (48 to 69 years). Pituitary tumor acromegaly history of 10 to 30 years, 2 cases have been treated pituitary tumor. Preoperative hormone levels and MRI and CT imaging examination. Colonoscopy biopsy confirmed colorectal cancer. All patients underwent colorectal surgery. Staging Dukes B, C period. After surgery are supplemented with chemotherapy. Postoperative complications of pulmonary infection, hypertension, hyperglycemia, hypokalemia, etc., were symptomatic improved, no anastomotic fistula, abdominal infection and other complications; 1 case was discharged automatically (lost after the visit). Seven cases were followed up for 2 to 44 months, all alive. Conclusion Pituitary growth hormone adenoma with colorectal cancer patients should be treated by colorectal cancer comprehensive treatment of pituitary adenomas according to the circumstances.