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尿素临床用其内服作利尿剂,外用作抗菌、消炎止痒及软化组织用,近年来,尿素软膏已成为皮肤科常用制剂之一。对其制剂及原料的含量测定,英国药典1980年版和美国药典19版均采用凯氏定氮法,此法非常繁琐费时,当测定软膏时,基质凡士林能形成表面张力较大的表层,易导致暴沸而使实验失败。为此,需寻找一种适合医院药房药检的简便易行、快速准确的测定方法。已报道的有“比
Urea clinical use of its internal use for diuretics, external use for anti-bacterial, anti-inflammatory antipruritic and soften tissue, in recent years, urea ointment has become one of dermatology commonly used agents. Determination of the preparation and raw materials, the British Pharmacopoeia 1980 edition and the United States Pharmacopoeia 19 Kjeldahl method are used, this method is cumbersome and time-consuming, when the determination of ointment, the matrix Vaseline can form a larger surface tension, easily lead to Bumping makes the experiment fail. Therefore, it is necessary to find a simple, rapid and accurate method for drug testing in hospital pharmacies. It has been reported that "than