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目的探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)与食管癌临床病理特征及预后的关系。方法采用免疫组织化学法检测92份食管癌组织,26份Ⅰ度不典型增生组织,17份Ⅱ/Ⅲ度不典型增生组织,89份正常食管黏膜组织(正常组)的EGFR表达情况,并分析EGFR与临床组织病理特征及预后的关系。结果正常组、Ⅰ度不典型增生组、Ⅱ/Ⅲ度不典型增生组、食管癌组中EGFR过表达率分别为0(0/89),19.23%(5/26),58.82%(10/17),69.57%(64/92);EGFR过表达在不同浸润深度,是否伴淋巴结转移上差异均有统计学意义(P<0.05);EGFR过表达阳性组与阴性组生存曲线差异有统计学意义(P<0.05)。结论 EGFR过表达与食管癌发生、发展及预后密切相关。
Objective To investigate the relationship between epidermal growth factor receptor (EGFR) and the clinicopathological features and prognosis of esophageal cancer. Methods The expression of EGFR in 92 esophageal cancer tissues, 26 atypical hyperplasia tissues of grade Ⅰ, 17 atypical hyperplasia of Ⅱ / Ⅲ degree and 89 normal esophageal mucosa tissues (normal group) were detected by immunohistochemistry Relationship between EGFR and clinical pathological features and prognosis. Results The overexpression rates of EGFR in normal group, atypical hyperplasia group Ⅰ, dysplasia group Ⅱ / Ⅲ and esophageal carcinoma group were 0 (0/89), 19.23% (5/26), 58.82% (10 / 17) and 69.57% (64/92), respectively. There was significant difference in EGFR overexpression between different depths of invasion and lymph node metastasis (P <0.05). The survival curves of EGFR positive group and negative group were statistically different Significance (P <0.05). Conclusion EGFR overexpression is closely related to the occurrence, development and prognosis of esophageal cancer.