患者女， 31岁，咳嗽、胸痛、低热 1年半，双下肢水肿，四肢多发紫黑色斑伴血疱、溃疡 3个月。入院时体温 38℃，肝脾肿大，皮肤大量瘀斑、血疱、陈旧性瘢痕和溃疡； ANA 1∶ 1280，抗 dsDNA 1∶ 20；胸片示胸腔积液；病理示坏死性血管炎伴白色血栓。经使用皮质类固醇和对症处理后，病情好转。往院第 10日，突然癫痫大发作，抢救后好转出院，后失访。 Patient, 31 years old, cough, chest pain, fever 1 and a half years, both lower extremity edema, multiple limbs purple black spot with blood blisters, ulcers 3 months. Body temperature at admission 38 ℃, hepatosplenomegaly, large skin ecchymosis, blood blisters, old scars and ulcers; ANA 1:1280, anti-dsDNA 1:20; chest X-ray showed pleural effusion; pathological necrotizing vasculitis White thrombus. After using corticosteroids and symptomatic treatment, the condition improved. To the hospital on the 10th, a sudden epileptic seizures, after the rescue was discharged, lost after the visit.