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大约60%~65%的男性不育症是特发性的,尽管其具体病因尚未明了,但遗传因素起着重要作用。研究表明,表观遗传修饰,包括DNA甲基化、翻译后组蛋白修饰、染色质重塑等,在特发性男性不育中均起到一定的作用。此外,全甲基化异常和特定区域甲基化异常均与精子质量低下、生育能力下降有关;已确认1 881种miRNA与男性生育功能相关;piRNA、IncRNA、circRNA等非编码RNA也在男性生殖中发挥调控作用。本文针对表观遗传学在男性不育症病因中所起的作用、将来可能的治疗策略等方面做一综述,为阐明男性不育的发生机制、建立新的诊治方法和预测工具等提供相关的研究基础。
About 60% to 65% of male infertility is idiopathic, although the exact cause is unknown, but genetic factors play an important role. Studies have shown that epigenetic modifications, including DNA methylation, posttranslational histone modification, chromatin remodeling, play a role in idiopathic male infertility. In addition, all methylation abnormalities and methylation abnormalities in specific regions are related to the low sperm quality and fertility decline; 1 881 miRNAs have been identified as related to male reproductive function; non-coding RNAs such as piRNA, IncRNA and circRNA are also found in male reproductive Play a regulatory role. In this paper, we review the role of epigenetics in the etiopathogenesis of male infertility and possible treatment strategies in the future. In order to clarify the mechanism of male infertility and establish new diagnosis and treatment methods and prediction tools, research Foundation.