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目的探讨血清瘦素、TNFα及HA、PCⅢ等指标在酒精性肝病患者的表达情况,为临床早期干预提供依据。方法用放射免疫分析法测定20例正常成人和49例酒精性肝病患者的血清瘦素、TNFα及HA、PCⅢ水平。结果酒精性脂肪肝(AFL)组、酒精性肝炎(HA)组、正常对照(NC)组血清瘦素、TNFα及HA、PCⅢ水平分别为(5.79±2.96)μg/L、(0.95±0.53)μg/L、(127.73±32.37)μg/L、(116.23±21.97)μg/L,(9.94±4.67)μg/L、(1.14±0.21)μg/L、(171.45±72.23)μg/L、(142.42±63.14)μg/L,(3.86±2.87)μg/L、(0.69±0.12)μg/L、(118.49±28.94)μg/L、(107.37±22.81)μg/L,AFL组血清瘦素、TNFα水平与NC组比较有显著性差异(P<0.05);AH组清瘦素、TNFα、HA和PCⅢ水平与NC组比较有显著性差异(P<0.05、P<0.01);AFL组血清瘦素、TNFα、HA水平与AH组比较亦有显著差异(P<0.05、P<0.01)。结论早期检测酒精性肝病患者血清瘦素、TNFα水平,对延缓肝纤维化进展有益。
Objective To investigate the expression of serum leptin, TNFα, HA and PCⅢ in patients with alcoholic liver disease and provide basis for early clinical intervention. Methods Serum leptin, TNFα, HA and PCⅢ levels were measured by radioimmunoassay in 20 normal adults and 49 patients with alcoholic liver disease. Results The levels of serum leptin, TNFα and HA and PCⅢ in alcoholic fatty liver (AFL) group, alcoholic hepatitis (HA) group and normal control group were (5.79 ± 2.96) μg / L, (0.95 ± 0.53) (127.73 ± 32.37) μg / L, (116.23 ± 21.97) μg / L, (9.94 ± 4.67) μg / L, 1.14 ± 0.21μg / L and 171.45 ± 72.23μg / 142.42 ± 63.14 μg / L, 3.86 ± 2.87 μg / L, 0.69 ± 0.12 μg / L, 118.49 ± 28.94 μg / L and 107.37 ± 22.81 μg / TNFα, HA and PCⅢ levels in AH group were significantly different from those in NC group (P <0.05, P <0.01); serum leptin level in AFL group was significantly lower than that in NC group (P <0.05) The levels of TNFα, TNFα and HA were also significantly different from those in AH group (P <0.05, P <0.01). Conclusions Early detection of serum leptin and TNFα levels in patients with alcoholic liver disease is beneficial to delay the progression of liver fibrosis.