1例50岁女性患者因反复肝功能异常不规律口服甘草酸二铵肠溶胶囊约22个月，后改用复方甘草酸苷3片、3次/d。复方甘草酸苷治疗4个月后，患者出现肌肉疼痛伴乏力，症状逐渐加重，以致四肢无力，行走困难。停用复方甘草酸苷1周，但症状未见好转，血压160/100 mmHg（1 mmHg=0.133 kPa）。实验室检查：血钾1.9 mmol/L，丙氨酸转氨酶（ALT）54 U/L，天冬氨酸转氨酶（AST）104 U/L，肌酸激酶（CK）>2 200 U/L，肌红蛋白542.1 μg/L，血pH 7.56。给予静脉和口服补钾及对症治疗，3 d后患者四肢乏力及肌痛症状明显好转，血钾恢复至3.5 mmol/L；2周后，患者肌力恢复正常，血压100/71 mmHg，血钾4.2mmol/L，ALT 45 U/L，AST 38 U/L，CK 44 U/L。为明确诊断，行醛固酮体位激发试验及卡托普利抑制试验，结果示醛固酮水平正常、肾素浓度降低。诊断为假性醛固酮增多症合并低钾性横纹肌溶解，考虑与长期服用甘草酸制剂有关。“,”A 50-year-old female patient was treated with diammonium glycyrrhizinate enteric-coated capsules for about 22 months irregularly due to repeated abnormal liver function, which was changed to compound glycyrrhizin 3 tablets thrice daily later. After 4 months of treatment with compound glycyrrhizin, the patient developed myalgia with fatigue and the symptoms gradually aggravated, resulting in weakness of limbs and difficulty in walking. Compound glycyrrhizin were stopped for 1 week, but the symptoms were not improved, with a blood pressure of 160/100 mmHg. Laboratory tests showed blood potassium 1.9 mmol/L, alanine aminotransferase (ALT) 54 U/L, aspartate aminotransferase (AST) 104 U/L, creatine kinase (CK) >2 200 U/L, myoglobin 542.1 μg/L, and blood pH 7.56. Intravenous and oral potassium supplementation and symptomatic treatments were given. Three days later, the symptoms of myalgia and fatigue were markedly improved and the blood potassium returned to 3.5 mmol/L. Two weeks later, the patient′s muscle strength recovered and the blood pressure was 100/71 mmHg. Laboratory tests showed blood potassium 4.2 mmol/L, ALT 45 U/L, AST 38 U/L, and CK 44 U/L. Aldosterone postural stimulation test and captopril challenge test were performed for definite diagnosis, showing normal aldosterone level and decreased renin concentration. Pseudoaldosteronism complicated with hypokalemic rhabdomyolysis was diagnosed, which was considered to be related to long-term administration of glycyrrhizic acid preparations.