16种不同抗癌药物的致癌作用,通过BR46特种的雄鼠试验后,所有烷化类药物都显示或多或少强烈的致癌作用。在短期试验中(手术后化疗预防),环磷酰胺和丝裂霉素也有致癌作用,而长春硷却无。除秋水仙碱类药物外,其余生物硷都无致癌作用,抗代谢药物也如此。甲基苄肼显示显著致癌作用。在长期试验中所见到的癌有白血球形成组织增生(包括骨髓增生和淋巴组织增生)、淋巴瘤、肺、肾、肝和乳腺癌以及原因不明的腹腔内肉瘤。近年来的抗癌药物,有些不会致癌,但另一些是强致癌剂。后者当绝对需要时(即手术后化学预防)再使 After the carcinogenic effects of 16 different anticancer drugs, all alkylated drugs showed more or less strong carcinogenesis after being tested by BR46 male mice. In the short-term trial (post-operative chemoprevention), cyclophosphamide and mitomycin also had carcinogenic effects, while Changchun had none. With the exception of colchicines, none of the other caries have carcinogenic effects, as do anti-metabolic drugs. Procarbazine shows a significant carcinogenic effect. Among the cancers seen in long-term trials are leukoplakia-forming tissue hyperplasia (including myeloproliferative and lymphoid tissue hyperplasia), lymphoma, lung, kidney, liver and breast cancer, and intra-abdominal sarcoma of unknown cause. Some anti-cancer drugs in recent years, some will not cause cancer, but others are strong carcinogens. When the latter is absolutely needed (ie post-operative chemoprophylaxis)