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目的 评价局部动脉内溶栓在急性缺血性脑中风治疗中的作用。方法 11例急性缺血性脑中风患者 ,采用局部动脉内灌注尿激酶 (UK)溶栓 ,所有病例均在发病 10h内接受治疗。入院时平均脑中风评分 (NIHS)为 18分。均为大脑中动脉 (MCA)闭塞。术后 3 0d用RankinScale(RS)标准评估疗效。结果 7例 (63 .6% )闭塞获得完全再通 ,1例 (9% )部分再通后并发颅内出血。 3例(2 7.3 % )无效。术后 3 0d ,2例 (18.2 % )完全恢复 (RS 0～ 1分 ) ,5例 (4 5 .5 % )轻度神经功能障碍 (RS 2～ 3分 ) ,4例 (3 6.3 % )重度神经功能障碍 (RS 4～ 5分 ) ,无死亡。结论 早期 (6h内 )局部动脉内溶栓是治疗急性缺血性脑中风的有效方法
Objective To evaluate the role of intra-arterial thrombolysis in the treatment of acute ischemic stroke. Methods Eleven patients with acute ischemic stroke were treated with local arterial infusion of urokinase (UK). All cases were treated within 10 hours of onset. The mean stroke score (NIHS) at admission was 18 points. All were middle cerebral artery (MCA) occlusion. The effect of RankinScale (RS) was evaluated 30 days after operation. Results Seven patients (63.6%) had complete recanalization, and one patient (9%) recurred after intracranial hemorrhage. 3 cases (2 7.3%) were invalid. There were 2 (18.2%) complete recovery (RS 0 ~ 1), 5 (45.5%) mild neurological deficits (RS 2 ~ 3) and 4 (3 6.3% Severe neurological dysfunction (RS 4 ~ 5), no death. Conclusion Early intra-arterial thrombolysis (within 6 hours) is an effective method for the treatment of acute ischemic stroke