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目的:观察中西医结合治疗骨性关节炎的疗效和安全性。方法:将184例患者随机分为2组各92例,对照组采用尼美舒利分散片和硫酸氨基葡萄糖片治疗,治疗组在对照组治疗基础上加用补肾祛瘀化痰汤。治疗2月后观察观察临床症状、体征、关节功能和日常生活能力等的改善程度,血沉(ESR)和C-反应蛋白(CRP)等改善情况及不良反应。结果:2组随访率相近(P>0.05)。2组治疗后关节肿痛积分、僵硬积分均减少(P<0.05),活动功能显著改善(P<0.05),ESR和CRP亦显著下降(P<0.05)。治疗组2月后关节肿痛积分、僵硬积分、关节活动功能积分、ESR和CRP与对照组比较,差异均有显著性意义(P<0.05),治疗组改善优于对照组。治疗组不良反应的发生少于对照组(P<0.05)。结论:补肾祛瘀化痰汤联合西药治疗骨性关节炎较单用西药疗效显著,且不良反应轻微,值得临床应用。
Objective: To observe the efficacy and safety of integrated traditional Chinese and western medicine in the treatment of osteoarthritis. Methods: 184 patients were randomly divided into 2 groups of 92 cases. The control group was treated with nimesulide dispersible tablets and glucosamine sulfate tablets. The treatment group was treated with Bushenquyu Huatan Decoction on the basis of the control group. After 2 months of treatment, the improvement of clinical symptoms, signs, joint function and daily living ability, improvement of ESR and CRP, and adverse reactions were observed. Results: The follow-up rates of two groups were similar (P> 0.05). The scores of joint swelling and pain, joint stiffness scores and stiffness scores of the two groups were decreased (P <0.05), activity function was significantly improved (P <0.05), ESR and CRP were significantly decreased (P <0.05). The pain score, stiffness score, joint function score, ESR and CRP in the treatment group after 2 months were significantly different from those in the control group (P <0.05). The treatment group improved more than the control group. Adverse reactions occurred less frequently in the treatment group than in the control group (P <0.05). Conclusion: Bushen Quyu Huatan Decoction combined with Western medicine treatment of osteoarthritis than Western medicine alone significantly effect, and mild adverse reactions, is worth clinical application.