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CC16是细支气管无纤毛上皮细胞———Clara细胞分泌的主要蛋白之一,能抑制磷脂酶A2 (PLA2 )的活性[1] ,是重要的内源性抗炎物质。我们的实验通过免疫组化和免疫印迹法(WesternBlot) ,检测小鼠支气管哮喘(简称哮喘)模型肺内CC16合成和分泌量的变化,同时用抗氧化剂N 乙酰半胱氨酸
CC16 is one of the major proteins secreted by bronchial epithelial cells, Clara cells. It inhibits phospholipase A2 (PLA2) activity [1] and is an important endogenous anti-inflammatory substance. In our experiment, the CC16 synthesis and secretion in the lung of mice with bronchial asthma (asthma) model were detected by immunohistochemistry and Western Blotting. At the same time, the antioxidant activity of N-acetylcysteine