论文部分内容阅读
目的探讨周围性听功能障碍程度与认知障碍程度之间的关系。方法利用临床痴呆量表(clinicdementiarating, CDR)检测轻度认知障碍(mildcognitiveimpairment,MCI)患者24例,轻度老年性痴呆(Alzheimer′sdisease, AD)患者31例,健康老年人50例,评定受试者测听可信度,统计测试结果,并将其得分同受试者的纯音测听、言语测听、声导抗、听觉脑干反应(auditorybrainstemresponse, ABR)结果进行对照分析,寻找二者之间的关系。并进一步将受试者按其听力损失程度分成4级(纯音听阈<25dB为0分, 25~30dB为1分, 31~35dB为2分, >35dB为3分),分别依其CDR得分不同(正常人0分,MCI患者0 5分,轻度AD患者1分),应用Kendalls等级相关法分析。结果受试者2耳间听力差异无统计学意义,以右耳听力结果进行统计,发现MCI组周围听功能检查结果与对照组之间的差异无统计学意义(P>0 05),轻度AD组听力障碍与其他两组相比差异有统计学意义,且发现随着听力损失的加重,轻度AD患者的CDR得分也明显增加(Kendallstaub=-0 285, P=0 018)。而测听可信度、声导抗和ABR阈值两组间差异无统计学意义(P>0 05 )。结论MCI患者与正常老年聋纯音测听、言语测听结果相似,轻度AD患者与MCI及正常对照组相比差异有显著性,受试者听力障碍程度与其CDR量表得分呈正相关(
Objective To explore the relationship between the degree of peripheral auditory impairment and cognitive impairment. Methods Twenty-four patients with mild cognitive impairment (MCI), 31 with mild Alzheimer’s disease (AD) and 50 with healthy elderly were assessed with the clinic dementia rating (CDR) The participants measured the credibility, measured the test results, and compared their scores with the pure tone audiometry, speech audiometry, acoustic impedance and auditory brainstem response (ABR) results of the subjects, looking for both The relationship between. Subjects were further divided into 4 grades according to their degree of hearing loss (pure tone threshold <25dB 0, 25-30dB 1, 31-35dB 2,> 35dB 3) (0 in normal subjects, 0 in MCI patients, and 1 in mild AD patients) were analyzed by Kendalls rank correlation analysis. Results There was no significant difference in the hearing between the two ears of the subjects, and the results of the right ear hearing were used for statistical analysis. There was no significant difference between the auditory function test results of the MCI group and the control group (P> 0.05) The hearing loss in AD group was significantly different from the other two groups, and it was found that with the increase of hearing loss, CDR scores of patients with mild AD were significantly increased (Kendallstaub = -0 285, P = 0 018). There was no significant difference between the two groups in reliability of audiometry, acoustic impedance and ABR threshold (P> 0.05). Conclusion The results of pure tone audiometry and verbal audiometry in MCI patients are similar to those of normal senile deaf patients. There is a significant difference between mild AD patients and MCI and normal controls, and the degree of hearing impairment is positively correlated with their CDR scale