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目的:观察芹灵冲剂对动物的急性、长期毒性及中毒靶器官,为临床安全用药提供依据。方法:急性毒性实验用小鼠以口服和腹腔给药,分别测定LD50 和MDT,并推算出相当临床人用量的倍数。长期毒性实验用大白鼠,设30g·kg-1 、10g·kg-1 两个剂量组和生理盐水对照组,连续灌服90d,观察动物的饮食、体重。于实验第45d、90d 和停药后28d,分别各处死1/3动物,取血测定血常规及其生化指标,并取出主要脏器作组织病理学检查。结果:芹灵冲剂的口服LD50 未能测出,MTD为100g·kg-1 ,相当于人临床用量的200 倍。注射剂腹腔注射LD50 为19.73g·kg-1 。芹灵冲剂慢性毒性实验,大鼠连续灌服90d,小剂量10g·kg-1 和大剂量30g·kg-1 组动物饮食、体重正常,血液及生化指标均未见异常,主要脏器组织学观察未见病理改变。结论:芹灵冲剂口服用药,连续服用较安全
OBJECTIVE: To observe the acute and long-term toxicity and target organs of poisoning of celery granules in animals, and provide basis for clinical safe drug use. METHODS: Acute toxicity experiments were performed in mice orally and intraperitoneally, and LD50 and MDT were measured, respectively, and the multiples of quite a few people were deduced. Long-term toxicity test rats, set 30g · kg-1, 10g · kg-1 two dose groups and saline control group, continuous gavage 90d, observe the animal’s diet, body weight. At the 45th day of the experiment, 90 days after the withdrawal, and 28 days after the discontinuation, 1/3 of the animals were sacrificed. Blood was collected to measure the blood routine and biochemical indicators, and the main organs were removed for histopathological examination. RESULTS: The oral LD50 of Qinling Granules could not be measured and the MTD was 100 g·kg-1 , which was equivalent to 200 times of the human clinical dosage. Injections of LD50 for intraperitoneal injection were 19.73 g·kg-1. In the chronic toxicity test of celery granules, the rats were continuously fed for 90 days. The small doses of 10 g.kg-1 and 30 g.kg-1 of large doses were normal in diet and weight, and there were no abnormalities in blood and biochemical indicators. The main organs were histologically studied. No pathological changes were observed. Conclusion: It is safer to take oral medication with Qinling Granules.