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本文报道苔黑酚和苔色酸丁酯的致突变研究。在有或无大鼠肝微粒体酶代谢活化条件下,经Ames法的TA97、TA98、TA100和TA102菌株行点试验和平皿掺入试验、中国仓鼠肺细胞(CHL细胞)的染色体畸变试验和小鼠背髋嗜多染色细胞(PCE)微核试验,结果:检品各剂量组分别与其相应的空白对照和/或溶剂对照组比较,均无显著差异。表明两种药物无诱发突变的作用。
This article reports the arcutin and moss butyl acid mutagenesis. In the presence or absence of rat liver microsomal enzyme metabolic activation conditions, the Ames method of TA97, TA98, TA100 and TA102 strains point experiments and plate incorporation test, Chinese hamster lung cells (CHL cells) chromosome aberration test and small The results showed that there was no significant difference between each dose group and the corresponding blank control group and / or solvent control group. Show that the two drugs have no effect of mutation.