伴有巨块淋巴结肿大的良性窦组织细胞增生症(Sinus histiocytosis with missivelymphadenopathy,简称SHML)是一种罕见的良性淋巴结病变。1960年Lenner首次描述了1例78岁的有眼、鼻、咽硬结病的病人,其淋巴结有特殊的病理学改变:扩张的淋巴窦内有大量的组织细胞伴有吞噬淋巴细胞、中性粒细胞及浆细胞、红细胞现象;淋巴结内有大量的浆细胞。1969年Rosai及Dorfman报告4例并命名为SHML。1972年他们共收集了34例。在完整地分析了其独特的形态学改变及良性的临床经过之后,确认了 Sinus histiocytosis with missively mphadenopathy (SHML) is a rare benign lymphadenopathy with massive lymphadenopathy. In 1960, Lenner first described a 78-year-old patient with ocular, nasal, and pharyngeal sclerosis. His lymph nodes had a special pathological change: a large number of histological cells in the expanded lymphatic sinus with phagocytic lymphocytes and neutrophils. Cells and plasma cells, red blood cell phenomenon; there are a large number of plasma cells in lymph nodes. In 1969, Rosai and Dorfman reported 4 cases and named it SHML. In 1972 they collected a total of 34 cases. After a complete analysis of its unique morphological changes and benign clinical course, it was confirmed