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目的研究重型颅脑损伤后患者凝血功能的变化及其对预后判断的价值。方法选取66例重型颅脑损伤患者作为观察组,分别在入院急诊时(D0)及入院后第2(D2)、3(D3)、7(D7)天检测活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(DD),并以同期66例单纯头皮裂伤患者作为对照组,D0检测凝血功能指标。对两组D0期的凝血功能检测结果进行分析和比较。结果两组比较,D2、D7的APTT值,D0、D2的PT值,D0、D2、D3的FIB值差异均具有统计学意义(P<0.05);TT值各时段和对照组比较,差异均无统计学意义(P>0.05)。结论重型颅脑损伤患者的凝血功能异常较明显,测定相关凝血功能指标,对颅脑损伤的严重程度及预后判断有参考价值。
Objective To study the changes of coagulation function and its prognostic value in patients with severe craniocerebral injury. Methods Sixty-six patients with severe craniocerebral injury were selected as the observation group. The activated partial thromboplastin time (APTT) was measured at admission emergency (D0) and on the 2nd (D2), 3 (D3) and 7 (D7) , Prothrombin time (PT), thrombin time (TT), fibrinogen (FIB) and D-dimer (DD). 66 patients with scalp laceration at the same period were used as the control group. index. The coagulation test results of two groups D0 were analyzed and compared. Results The differences of APTT values, D0, D2 PT values, D0, D2, D3 FIB values between D2 and D7 were statistically significant (P <0.05). Compared with control group, No statistical significance (P> 0.05). Conclusion Patients with severe craniocerebral injury have obvious coagulation abnormalities. The indexes of coagulation function can be measured, which has reference value for the severity of craniocerebral injury and prognosis.