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目的观察消瘤汤应用于脾虚痰湿型中晚期非小细胞肺癌疗效。方法 108例中晚期非小细胞肺癌患者随机分为观察组(51例)和对照组(57例)。观察组和对照组均用NP方案(顺铂d1~3,长春瑞滨d1,8)化疗,观察组同时加用消瘤汤治疗,观察两组患者治疗后的症状、生存质量、病灶和免疫功能的变化情况。结果治疗后观察组生活质量比对照组提高明显(P<0.01);观察组临床症状比对照组改善明显(P<0.05);观察组患者淋巴细胞转换率及T细胞亚群较对照组明显提高(P<0.05)。结论消瘤汤配合化疗较单用化疗可以显著改善脾虚痰湿型中晚期非小细胞肺癌患者的临床症状和生活质量,机制与消瘤汤具有抗肿瘤、提高机体免疫力的功能有关。
Objective To observe the effect of Xiaoyao Decoction on advanced non-small cell lung cancer with spleen deficiency and phlegm type. Methods One hundred and eighty patients with advanced non-small cell lung cancer were randomly divided into observation group (n = 51) and control group (n = 57). The observation group and the control group were treated with NP regimen (cisplatin d1 ~ 3, vinorelbine d1,8). The observation group was treated with Xiaoyu Tang at the same time. The symptoms, quality of life, lesions and immunity after treatment in both groups were observed Functional changes. Results After treatment, the quality of life in the observation group was significantly higher than that in the control group (P <0.01); the clinical symptoms in the observation group were significantly improved (P <0.05); the lymphocyte transformation rate and T cell subsets in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Xiaoyu decoction combined with chemotherapy can significantly improve clinical symptoms and quality of life in patients with advanced non-small cell lung cancer of spleen deficiency and phlegm-dampness. The mechanism is related to its function of anti-tumor and immunity enhancement.