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【目的】探讨冠心病(CHD)患者血浆 miRNA155、肿瘤坏死因子α(TNF-α)变化水平及相关性研究。【方法】选择2013年12月至2014年6月本院收治的75例 CHD患者。将其分为两组,急性冠状动脉综合征(ACS)组(39例)和慢性心肌缺血综合征(CIS)组(36例)；同时选择同期来本院健康体检者34例作为对照组。对比分析三者基础资料、血浆 TNF-α、microRNA155变化,以及 ACS 组和 CIS 组血浆 miRNA155与TNF-α相关性。【结果】ACS组TNF-α、miRNA155水平显著高于CIS组和对照组,CIS组TNF-α、miRNA155水平显著高于对照组,差异均具有统计学意义(均P <0.05)。血浆miRNA155与TNF-α呈显著正相关(r=0.784,P <0.05)。【结论】CHD患者血浆 miRNA155、TNF-α水平显著升高,血浆 miRNA155和TNF-α水平呈显著正相关性。“,”Obj ective]To explore the correlation and the changes between plasma micro RNA1 5 5 and TNF-αof coronary artery disease patients.[Methods]Seventy-five cases of patients with coronary artery dis-ease who were diagnosed from December 2013 to June 2014,were selected and divided into acute coronary syn-drome(ACS,n=39)and chronic ischemic syndrome (CIS,n=36)and at the same time 34 cases of healthy people who underwent health exam were chosen as the control group .Comparison and analysis of the basic da-ta,the changes in plasma TNF-αlevel and microRNA155,and the correlation between plasma miRNA155 and TNF-αin ACS group and CIS group were performed.[Results]The levels of TNF-αin the ACS Group were significantly higher than that in the CIS group and the control group.The levels of TNF-αin the CIS group were notably higher than that in the control group,with statistical difference(both P <0.05).Plasma miR-NA155 was positively correlated with TNF-α(r =0.784 R,P <0.05).[Conclusion]The levels of plasma miRNA155 and TNF-αare significantly increased in CHD patients,and the levels of plasma miRNA155 and TNF-αare positively correlated with.