论文部分内容阅读
回顾性分析我院收治的133例糖尿病并冠心病患者的临床资料,将27例阿司匹林抵抗的患者分为A组,106例非阿司匹林抵抗的患者分为B组。对比两组的各项临床资料,通过Logistic回归分析探讨糖尿病并冠心病患者发生阿司匹林抵抗的危险因素。结果:A组糖尿病病程、同型半胱氨酸、空腹血糖、总胆固醇、低密度脂蛋白胆固醇以及糖化血红蛋白均显著高于B组,而高密度脂蛋白胆固醇显著低于B组(均P<0.05);Logistic回归分析显示,同型半胱氨酸、空腹血糖、总胆固醇、低密度脂蛋白胆固醇是糖尿病并冠心病患者发生阿司匹林抵抗的危险因素(均P<0.05)。结论:糖尿病并冠心病患者容易发生阿司匹林抵抗,临床上应强化控制血糖、降低胆固醇、低密度脂蛋白胆固醇和同型半胱氨酸的水平,以提高阿司匹林对心血管事件的防治效果。
Retrospective analysis of 133 cases of diabetic patients with coronary heart disease in our hospital clinical data, 27 patients with aspirin resistance were divided into A group, 106 patients were divided into non-aspirin resistance group. The clinical data of two groups were compared. Logistic regression analysis was used to explore the risk factors of aspirin resistance in patients with diabetes mellitus and coronary heart disease. Results: The duration of diabetes, homocysteine, fasting blood glucose, total cholesterol, low density lipoprotein cholesterol and glycosylated hemoglobin in group A were significantly higher than those in group B, while those of high density lipoprotein cholesterol were significantly lower than those in group B (all P <0.05 ). Logistic regression analysis showed that homocysteine, fasting blood glucose, total cholesterol and low density lipoprotein cholesterol were risk factors of aspirin resistance in patients with diabetes and coronary heart disease (all P <0.05). CONCLUSION: Aspirin resistance is prone to occur in patients with diabetes and coronary heart disease. In clinical practice, blood glucose should be controlled intensively to lower the levels of cholesterol, LDL-C and homocysteine to improve the prevention and treatment of aspirin’s cardiovascular events.