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从两例人肺腺癌组织中分离出淋巴细胞。在体外重组白细胞介素-2条件下培养,在一段时间内出现持续增殖。病例A经45天培养淋巴细胞数扩增约267倍。病例B经32天培养淋巴细胞数扩增约87倍。肿瘤浸润性淋巴细胞在体外白细胞介素-2条件下培养,8～10天细胞毒活性明显提高,到15天达最高峰,维持约20天时间。
Lymphocytes were isolated from two human lung adenocarcinoma tissues. When cultured in vitro with recombinant interleukin-2, sustained proliferation occurs over a period of time. In Case A, the number of cultured lymphocytes increased by about 267 fold over 45 days. In case B, the number of lymphocytes cultured in 32 days was about 87 times larger. Tumor-infiltrating lymphocytes were cultured in vitro under the conditions of interleukin-2. The cytotoxic activity was significantly increased in 8 to 10 days, reached the highest peak by 15 days, and maintained for about 20 days.