【摘 要】
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Dear Editor,Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal and highly specialized fenestrated cells in the liver.LSECs differ
【机 构】
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National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing
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Dear Editor,Liver sinusoidal endothelial cells (LSECs) are the most abundant non-parenchymal and highly specialized fenestrated cells in the liver.LSECs differ from endothelial cells of other capillaries due to the presence of open fenestrations and the absence of a basal lamina (Wisse et al.,1996;Braet and Wisse,2002;Aird,2007;Cogger et al.,2008).During the differentiation process,LSECs become fenestrated to facilitate the transfer of circulating nutrients,lipids,and lipoproteins between blood and the space of Disse for normal liver metabolism.Only particles smaller than the fenestrae can reach the hepatocytes or leave the space of Disse (Wisse et al.,1985).The size of fenestration changes upon different conditions to regulate the substrate exchange.
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