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几位作者在各自对一急性早幼粒细胞性白血病(APL)患者的染色体研究中,发现了一种结果相似的异常核型,即染色体数为46个的假二倍体,15号染色体长臂2区2带与17号染色体长臂2区1带相互易位(或“插入”)。白血病性早幼粒细胞在第一名患者的周围血和骨髓中各占45%和75%;在第二名患者各占44%和43%;在第三名患者各占20%和45.6%。除第三名患者化疗后获得完全的血液学缓解7个月外,第一、二名患者在化疗开始二个月后分别死于大肠杆菌败血症和急性肾衰竭。作者们在化疗前以标准的Giemsa染色法、
Several authors found a similar abnormal karyotype in their chromosomal studies in an acute promyelocytic leukemia (APL) patient, namely a 46-chromosome pseudodiploid, chromosome 15 long The arm 2 region 2 band is reciprocally translocated (or “inserted”) with the long arm 2 region 1 band of chromosome 17. Leukemia-producing myelocytes accounted for 45% and 75% of peripheral blood and bone marrow in the first patient; 44% and 43% of patients in the second patient; 20% and 45.6% of patients in the third patient. . Except for the third patient who received complete hematologic remission after chemotherapy for 7 months, the first and second patients died of E. coli sepsis and acute renal failure two months after the start of chemotherapy. The authors used standard Giemsa staining before chemotherapy.