离体大鼠心脏在左冠状动脉结扎后15分钟,重新开放,实行“再灌流”,可立即引起心室纤颤(83.3%)。氨固酮(2.3×10~(-5)M)能完全防止此种心室纤颤之发生,并减少再灌流心脏糖元的消耗,但不能减少“缺血”心肌乳酸脱氢酶的释放。氨固酮在此标本上的作用性质与作用强度,与慢心律非常接近。 Isolated rat hearts were reopened 15 minutes after ligation of the left coronary artery, and “reperfusion” was performed. Immediate ventricular fibrillation (83.3%) was induced. Anesthetics (2.3 × 10 -5 M) completely prevented the occurrence of ventricular fibrillation and decreased cardiac glycogen consumption during reperfusion, but did not reduce the release of myocardial ischemia lactate dehydrogenase. The nature and intensity of action of the testosterone on this specimen is very similar to that of the slow heart rate.