目的 :探讨高能冲击波对肾脏形态学和功能的影响 ;界定体外震波碎石术的安全限量。方法 :30只雄性家兔随机分为两组 ,分别接受 3 5 0 0× 12kV(A组 )和 2 5 0 0× 12kV(B组 )的冲击实验。术后不同时相分别测定BUN、Cr、电解质变化 ,肾脏组织学和超微结构的变化。结果 :实验后第一周肾功能变化异常 ,但 7～ 14d恢复正常。组织学上 ,急性期主要表现为灶状出血和血肿形成。慢性期主要为肾小管扩张和间质纤维化。超微结构上主要为线粒体和内质网的变化。结论 :高能冲击波对肾脏的生物学效应主要引起近期的功能损害和远期永久性的局部组织纤维化改变 Objective: To investigate the impact of high-energy shock wave on renal morphology and function and to define the safety limits of extracorporeal shock wave lithotripsy. Methods: Thirty male rabbits were randomly divided into two groups and were subjected to impact experiments of 3550 × 12kV (group A) and 2550 × 12kV (group B) respectively. The changes of BUN, Cr, electrolyte, renal histology and ultrastructure were measured at different time points after operation. Results: The changes of renal function were abnormal in the first week after the experiment, but returned to normal after 7 ~ 14 days. Histologically, the acute stage mainly manifested as focal hemorrhage and hematoma formation. Chronic phase is mainly tubular dilatation and interstitial fibrosis. The ultrastructure is mainly the changes of mitochondria and endoplasmic reticulum. CONCLUSIONS: The biological effects of high-energy shock waves on the kidneys mainly result in recent functional impairment and long-term permanent changes in local tissue fibrosis