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本文介绍并综述了以ＣｏＭＦＡ、ＡＰＥＸ－３Ｄ、Ｌｕｄｉ和Ｌｅａｐｆｒｏｇ为代表的三维定量结构－活性关系研究方法的近况。作为药物分子设计的新方法，它们在新药设计和先导化合物的产生中起着越来越重要的作用。
This article describes and summarizes the current status of research methods of three-dimensional quantitative structure-activity relationship represented by CoMFA, APEX-3D, Ludi and Leapfrog. As a new method of drug molecule design, they play an increasingly important role in the design of new drugs and the generation of lead compounds.