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目的探讨叉头转录因子O亚族(forkhead transcription factors box class O,FOXO)单核苷酸多态性与肝细胞癌临床病理特征的关系。方法采用Taq Man-MGB高通量实时荧光定量聚合酶链式反应法对FOXO基因的3个多态性位点进行基因分型,运用2检验和多因素Logistic回归模型分析FOXO基因3个多态性位点与肝细胞癌临床病理特征的关系。结果携带rs4946936位点T等位基因的个体发生脉管侵犯的风险下降(P=0.038,OR=0.773,95%CI:0.606~0.986),携带rs4503258位点T等位基因的个体发生肝硬化的风险降低(P=0.034,OR=0.767,95%CI:0.600~0.980),携带rs17592236位点T等位基因的个体出现癌栓的风险增加(P=0.031,OR=1.244,95%CI:1.020~1.517)。结论 FOXO基因多态性与肝癌脉管侵犯、癌栓和肝硬化的发病风险相关,对肝癌的发展和生存的早期预测有重要参考价值。
Objective To investigate the relationship between single nucleotide polymorphisms of forkhead transcription factor box class O (FOXO) and the clinicopathological features of hepatocellular carcinoma. Methods Three polymorphic sites of FOXO gene were genotyped by TaqMan-MGB high-throughput real-time fluorescence quantitative polymerase chain reaction (PCR-RFLP). Χ2 test and multivariate logistic regression analysis were used to analyze the FOXO gene polymorphisms Relationship between clinicopathologic features and clinicopathological features of hepatocellular carcinoma. Results Individuals with the T allele at rs4946936 had a reduced risk of vascular invasion (P = 0.038, OR = 0.773, 95% CI: 0.606-0.986). Individuals with the T allele at rs4503258 had cirrhosis (P = 0.034, OR = 0.767, 95% CI: 0.600-0.980). The individuals with T allele rs17592236 had an increased risk of tumor emboli (P = 0.031, OR = 1.244, 95% CI: 1.020 ~ 1.517). Conclusion FOXO gene polymorphism is associated with the risk of vascular invasion, thrombus and cirrhosis of hepatocellular carcinoma, which is of important reference value for the development of hepatocellular carcinoma and early prediction of survival.