已知术前放疗或局部高温治疗对肠道吻合无影响,局部高温和放疗联合应用的生物学作用则令人关注,因为高温改善放疗的杀肿瘤作用。首先,放疗使肿瘤细胞缺氧和营养不良,其pH低下和灌注不良的环境使肿瘤细胞更易被高温损害。高温破坏膜脂蛋白,使不耐温的细胞酶发生变性,在24h内就杀死肿瘤细胞。其 It is known that preoperative radiotherapy or local hyperthermia treatment has no effect on bowel anastomosis, and the combined biological effects of local high temperature and radiotherapy are of concern because high temperatures improve the tumor killing effect of radiotherapy. First, radiotherapy renders tumor cells hypoxic and malnourished, and their low pH and poor perfusion environment make tumor cells more vulnerable to high temperatures. The high temperature destroys the membrane lipoproteins and denatures the thermostable cellular enzymes, killing the tumor cells within 24 hours. its