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目的了解2000～2012年中国手足口病(Hand,Foot and Mouth Disease,HFMD)爆发的流行病学特征,为预防和控制HFMD的爆发,以及相关疫苗免疫策略的制定提供参考。方法采用系统评价的方法,在中国医院知识数据库、万方数据库和维普数据库中检索相关文献,对符合条件文献的信息进行提取和分析。结果此次系统评价共收集符合条件的文献78篇,结果显示:HFMD爆发的平均罹患率2008年以来略有上升,3～6月为爆发高峰,城市罹患率(6.2%)高于农村(5.3%),中部地区罹患率(2.6%)低于东部(7.0%)和西部地区(6.9%),80.8%的HFMD爆发发生在托幼机构,爆发病例多集中在2～5岁儿童,男性多于女性。结论HFMD爆发的流行病学特征具有一定的规律性,应加强对HFMD爆发疫情的监测和报告,以便预防和控制HFMD的爆发。
Objective To understand the epidemiological characteristics of the outbreak of Hand, Foot and Mouth Disease (HFMD) in China from 2000 to 2012, and to provide references for the prevention and control of the outbreak of HFMD and the formulation of vaccination strategies. Methods A systematic review method was used to search related literature in China Hospital Knowledge Database, Wanfang Database and VIP Database, and to extract and analyze the information that meets the criteria. Results A total of 78 eligible articles were collected in this systematic review. The results showed that the average attack rate of HFMD outbreak increased slightly from 2008 to the peak of the outbreak in March to June, while the urban attack rate (6.2%) was higher than that in rural areas (5.3% (2.6%) in the central region was lower than that in the east (7.0%) and the western region (6.9%). 80.8% of the HFMD outbreaks occurred in the nurseries. Outbreaks were mostly found in children aged 2 to 5 years, with more males For women. Conclusion The epidemiological characteristics of HFMD outbreak have certain regularity. Monitoring and reporting on the outbreak of HFMD should be strengthened in order to prevent and control the outbreak of HFMD.