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目的:探讨氯吡格雷联合阿司匹林治疗老年冠心病(CHD)的临床疗效和安全性。方法:60例老年CHD患者随机分为治疗组和对照组。对照组采用阿司匹林治疗,治疗组采用氯吡格雷联合阿司匹林治疗,治疗4周后观察血小板聚集率(PAG)和凝血功能。结果:治疗4周后,治疗组PAG显著下降,APTT显著上升,与治疗前和对照组比较均有显著性差异(P<0.05);两组治疗前后PT、PA变化差异无统计学意义(P>0.05)。两组均未出现不良反应。结论:阿斯匹林联合氯吡格雷治疗老年CHD患者,较单用阿斯匹林治疗更能有效地抑制血小板聚集和预防血栓形成,并能得到更好的临床疗效。
Objective: To investigate the clinical efficacy and safety of clopidogrel combined with aspirin in the treatment of elderly patients with coronary heart disease (CHD). Methods: Sixty elderly CHD patients were randomly divided into treatment group and control group. The control group was treated with aspirin. The treatment group was treated with clopidogrel combined with aspirin. After 4 weeks of treatment, the platelet aggregation rate (PAG) and coagulation function were observed. Results: After 4 weeks of treatment, PAG decreased significantly and APTT increased significantly in treatment group compared with those before treatment and control group (P <0.05). There was no significant difference in PT and PA between the two groups before and after treatment (P > 0.05). No adverse reactions occurred in both groups. Conclusion: Aspirin combined with clopidogrel in elderly patients with CHD than aspirin alone is more effective in inhibiting platelet aggregation and preventing thrombosis, and can get better clinical efficacy.