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为了评估一种治疗过敏性鼻炎的草药复方胶囊剂并控制其质量 ,制定了HPLC法测定其中黄芩苷的方法 ,考察了该法的有效性并将该法应用于测定胶囊剂及其原汤剂中的该有效成分。试验表明用热沸水从草药提取黄芩苷是一种有效的制备方法 ;与浸膏混合的黄芩苷在水中的溶解度达 (1.5 6mg·mL-1) (37℃ ) ;在标准汤剂每日剂量中该标志成分的含量大大高于胶囊剂每日剂量中的含量。结果提示 ,浓缩的草药制剂应与其原标准汤剂在化学和药剂进行比较以便进一步优化处方及其产品
In order to evaluate a herbal compound capsule for the treatment of allergic rhinitis and to control its quality, a HPLC method was developed for the determination of baicalin, the effectiveness of the method was examined, and the method was applied to the determination of capsules and their original decoctions. This active ingredient. Tests have shown that extracting baicalin from hot herbs using hot boiling water is an effective preparation method; the solubility of baicalin mixed with extracts in water is (1.5 6 mg·mL-1) (37°C); daily dose in standard decoction The content of this ingredient in the mark is much higher than the daily dose of the capsule. The results suggest that concentrated herbal preparations should be compared with their original standard decoctions in chemistry and pharmaceuticals in order to further optimize prescriptions and their products.