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本研究通过每日给小鼠喂饲内含稀土(0.0625%,0.25%,1.0%)饮水10d后,经腹腔一次注射诱癌剂氨基甲酸乙酯后,再继续喂饲同样含稀土饮水共110d。观察稀土对小鼠肺癌发生抑制率以及小鼠抗肿瘤免疫功能和抗氧化功能的变化。结果发现,稀土处理组小鼠肺癌发生率比阳性组降低11.6%~31.3%,每只小鼠平均发生肿瘤数降低了35.7%~58.0%。同时还发现,促进小鼠NK细胞活力增加达46%~85%,并增加SOD活性,以及降低脂质过氧化物的含量。由此可见,轻稀土处理不仅可抑制小鼠肺癌发生率,还可提高小鼠免疫功能和抗氧化能力。
In this study, mice were fed daily with rare earth (0.0625%, 0.25%, 1.0%) for 10 days, and then the carcinogen urethane was injected intraperitoneally once and continued to be fed. The same rare earth drinking water for a total of 110d. Observed the inhibition rate of rare earth on lung cancer in mice and the change of anti-tumor immune function and anti-oxidation function in mice. The results showed that the incidence of lung cancer in the rare earth-treated group was 11.6% to 31.3% lower than that in the positive group, and the average number of tumors per mouse was reduced by 35.7% to 58.0%. At the same time, it was also found that the NK cell viability was increased by 46% to 85%, and the activity of SOD was increased, and the content of lipid peroxide was also decreased. Thus, light rare-earth treatment can not only inhibit the incidence of lung cancer in mice, but also improve the immune function and antioxidant capacity of mice.