论文部分内容阅读
作者曾证明,用γ射线灭活的恙虫立克次体免疫小鼠后,能保护小鼠免受致死剂量的同种立克次体感染;这种保护性免疫是细胞介导的,与抗体无关。活的恙虫病立克次体经皮下注射也可产生相同的保护性免疫。在本文中,作者进一步研究了γ射线灭活的恙虫病立克次体(Karp株)免疫BALB/C小鼠后引起的几种细胞免疫指标的变化,与此同时还与活恙虫病立克次体免疫的效果进行了比较。作者用2×10~7M LD_(50)。50%小鼠致死量的灭活恙虫病立克次体经腹腔注入BALB/C小鼠,每隔5天一次,共三次;另一组小鼠用1000M LD_(50)活恙虫病立克次体皮下注射,然后分别测定两组小鼠的迟发型超敏反应(DTH)、抗原诱导的淋巴细胞转化及抗原诱导的淋巴因子(MIF和IFN)等,结果表明:
The authors have demonstrated that immunization of mice with rickettsia tsutsugamushi inactivated by gamma rays protects mice from lethal doses of the same rickettsial infection; this protective immunity is cell-mediated, in contrast to antibodies Nothing to do Rickettsia tsutsugamushi live subcutaneously injected can also produce the same protective immunity. In this paper, the authors further studied the changes of several cellular immune indices induced by γ-ray inactivation of Rickettsia tsutsugamushi (Karp strain) after immunization of BALB / C mice, and at the same time, The effect of seminoma was compared. The author used 2 × 10 ~ 7M LD_ (50). 50% lethal dose of mice inactivated tsutsugamushi disease Rickettsia BALB / C mice were injected intraperitoneally once every 5 days, a total of three times; another group of mice with 1000M LD_ (50) Then subcutaneously injected, and then measured the delayed type hypersensitivity (DTH), antigen-induced lymphocyte transformation and antigen-induced lymphokines (MIF and IFN) in the two groups of mice respectively. The results showed that: