温热疗法有抗肿瘤的作用。Busch(1866)首先报道因罹患丹毒而发高热的肉瘤患者,肉瘤消失了。Caley(1893)注意了这个报道,把溶血性链球菌反复注入恶性肿瘤内看到温热对于恶性肿瘤是有作用的。Westermark(1898)报道说,对子宫颈癌进行高温水冲洗有效。进入到二十世纪,由于方法上没能突破难点,且有并发副作用的可能,对于恶性肿瘤已广泛应用放疗。六十年代试行各种加温的方法,于是又引起了关注。生物学基础早已确认,恶性肿瘤对温热比正常组织有更高的感受性。Lambert(1912)证明增殖肉瘤的小鼠在42～47℃的条件下,肉瘤组织死灭而正常组织无变 Thermotherapy has an anti-tumor effect. Busch (1866) first reported sarcoma patients who had high fever due to erysipelas. The sarcoma disappeared. Caley (1893) took note of this report and found that repeated injections of hemolytic streptococci into malignant tumors have a role in malignancy. Westermark (1898) reported that high-temperature water washing of cervical cancer is effective. In the 20th century, radiotherapy has been widely used for malignant tumors because it has failed to overcome difficulties and has the possibility of concurrent side effects. In the 1960s, various methods of heating were tried, and they also attracted attention. The biological basis has long been confirmed that malignant tumors are more sensitive to warmth than normal tissues. Lambert (1912) demonstrated that in sarcoma-producing mice, the sarcoma tissue died and the normal tissue remained unchanged at 42-47°C.