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目的 探讨胰岛素样生长因子 - 1 (IGF - 1 )、胰岛素样生长因子结合蛋白 - 3(IGFBP - 3)与老年男性骨质疏松患者骨密度的关系。方法 通过测定 60例老年男性骨质疏松患者及 60例对照组IGF - 1 ,IGFBP - 3及骨钙素 (BGP)、I型胶原异构C端肽 (β-CTX)等指标 ;同时测量骨密度 (BMD)。结果 老年男性骨质疏松患者腰椎和左股骨颈BMD显著低于对照组 (均P <0 .0 1 ) ;血清IGF - 1 ,IGFBP - 3低于对照组 (均P <0 .0 1 ) ;血清BGP低于对照组 (P <0 .0 5) ;血清 β-CTX高于对照组 (P <0 .0 5) ;而血钙 ,血磷水平在两者之间无显著差异 (P >0 .0 5) ,对照组和骨质疏松组腰椎侧位 ,左股骨颈BMD均与IGF - 1 ;IGFBP - 3 ;BGP呈正相关 ,与 β -CTX呈负相关 ,而与血钙、血磷无关。 结论 IGF - 1、IGFBP - 3、BGP、β -CTX水平都与骨含量具有良好的相关性。检测上述指标可作为诊断老年男性骨质疏松的一项参考指标
Objective To investigate the relationship between insulin - like growth factor - 1 (IGF - 1), insulin like growth factor binding protein - 3 (IGFBP - 3) and bone mineral density in elderly male patients with osteoporosis. Methods The indexes of IGF - 1, IGFBP - 3, BGP and β - CTX in 60 elderly osteoporosis patients and 60 controls were measured. Density (BMD). Results The BMD of lumbar spine and left femoral neck in elderly men with osteoporosis were significantly lower than those in control group (all P <0.01). The levels of IGF - 1 and IGFBP - 3 in serum were lower than those in control group (all P <0.01). Serum BGP was lower than that of the control group (P <0.05), serum β-CTX was higher than that of the control group (P <0.05), while serum calcium and phosphorus levels were not significantly different between the two groups (P> 0.05). BMD of lumbar vertebra and left femoral neck in control group and osteoporosis group were positively correlated with IGF - 1, IGFBP - 3 and BGP, but negatively correlated with β - CTX, but not with serum calcium, Nothing to do Conclusion The levels of IGF - 1, IGFBP - 3, BGP and β - CTX all have good correlation with bone content. Detection of these indicators can be used as a diagnosis of osteoporosis in older men, a reference index