蛋白激酶B(proteinkinaseB ,PKB) /Akt是一种丝氨酸 /苏氨酸蛋白激酶 ,传递生长因子等胞外刺激信号 ,参与调节细胞凋亡、增生、分化和代谢等一系列生理活动。最近在许多人类肿瘤中发现Akt频繁激活 ,在调节肿瘤细胞的增生、凋亡、代谢以及肿瘤血管生成方面发挥重要作用。 Protein kinase B (PKB) / Akt, a serine / threonine protein kinase, is involved in the regulation of apoptosis, proliferation, differentiation and metabolism through a series of physiological activities such as extracellular stimuli that transmit growth factors. Akt has recently been found to be frequently activated in many human tumors and plays an important role in the regulation of tumor cell proliferation, apoptosis, metabolism and tumor angiogenesis.