治疗哮喘病人最显著贡献之一是认识到过敏性哮喘病人接触抗原后所产生的二次或迟发应答,我们称为延缓相反应(LPR)。这是一种炎症反应。这种延缓相反应在皮肤、肺和鼻内均已观察到。 在这些反应中虽然单核细胞、中性白细胞、嗜碱细胞和嗜酸细胞也参加,但中性白细胞是其主要细胞。有证据表明,可溶性因子(来自中性白细胞的组织胺释放活性)刺激肥大细胞再脱颗粒从而诱发支气管出现超反应性。这种炎症成份亦可由刺激物如冷空气和臭氧以及感染性因子诸如病毒所诱 One of the most significant contributions to the treatment of asthma is the recognition of a secondary or delayed response to allergic asthma patients following antigen exposure, which we call Delayed Phase Response (LPR). This is an inflammatory reaction. The opposite of this delay has been observed in the skin, lungs and nose. Although monocytes, neutrophils, basophils and eosinophils are also involved in these responses, neutrophils are their major cells. There is evidence that soluble factors (histamine-releasing activity from neutrophils) stimulate mast cells to degranulate and induce bronchial hyper-reactivity. This inflammatory component can also be induced by irritants such as cold air and ozone as well as infectious agents such as viruses