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血小板第四因子(platelet factor 4,PF4),由激活的血小板分泌,在巨核细胞中合成,贮存于a-颗粒中的大分子蛋白聚糖,具有中和肝素、炎症趋化、抑制血管形成和巨核细胞生长的功能[1]。近年的研究多集中于研究PF4能可逆的抑制造血干(祖)细胞的生长,负性调节骨髓细胞增殖、分化,保护骨髓造血干(祖)细胞免受辐射和细胞毒剂的损伤;而关于血小板第四因子与心脑血管疾病的相关性研究,国内外报道较少,现简要综述。
Platelet factor 4 (PF4), macrophage proteoglycan secreted by activated platelets, synthesized in megakaryocytes and stored in a-particles, has the ability to neutralize heparin, chemotaxis of inflammation, inhibition of angiogenesis and Megakaryocyte growth function [1]. In recent years, many studies have focused on the research that PF4 can reversibly inhibit the growth of hematopoietic stem (progenitor) cells, negatively regulate the proliferation and differentiation of bone marrow cells and protect the bone marrow hematopoietic stem (progenitor) cells from radiation and cytotoxic agents; The fourth factor and cardiovascular and cerebrovascular disease research, less reported at home and abroad, is a brief review.