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自1917年Tyzzer在癌移植实验的小鼠中,发现以肝多发性灶坏死和出血坏死性肠炎为主要特征的本传染病以来,已在其他动物如大鼠、仓鼠、豚鼠、家兔、犬中相继发现。此病原体的存在对癌症等实验性研究有严重影响,故被公认列为无特定病原体动物应排除的病原体。该病原体呈细长形,比细菌大,易自溶,且只能在活细胞内生长。诊断该病的方法除了特征病变外,尚未完全确立。近年来国外报告应用补体结合试验和间接免疫荧光试验监测。1985年,本实验室应用微量补体结合试验的方法,对实验小鼠泰泽氏病原体抗体作了检测,结果证实本中心各小鼠群均未受到该病的感染。现报告如下:
Since 1917 Tyzzer found in cancer-transplanted mice that this infectious disease characterized mainly by multiple hepatic necrosis and hemorrhagic necrotizing enterocolitis has been found in other animals such as rats, hamsters, guinea pigs, rabbits, dogs In succession have been found. The presence of this pathogen has serious implications for experimental studies such as cancer and is therefore recognized as a pathogen that should be excluded as an animal without a specific pathogen. The pathogen is slender, larger than bacteria, self-dissolving and can only grow inside living cells. The method of diagnosing the disease has not yet been fully established except for the characteristic lesions. In recent years, foreign reports using complement fixation test and indirect immunofluorescence test monitoring. In 1985, our laboratory applied the method of trace complement fixation test to test the antibody against Tyzine’s pathogen in experimental mice, which confirmed that none of the mice in this center were infected with the disease. The report is as follows: