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瞬时受体电位阳离子通道6(TRPC6)是足细胞实现滤过屏障功能的关键分子之一。在一些获得性和遗传性的肾脏疾病中常发现其足细胞上TRPC6呈过度表达,在动物模型中TRPC6的过表达能导致蛋白尿。本文探讨了TRPC6的过表
Transient receptor potential cation channel 6 (TRPC6) is one of the key molecules in podocyte filtration barrier function. TRPC6 is often overexpressed on podocytes in some acquired and hereditary kidney disease. Over-expression of TRPC6 leads to proteinuria in animal models. This article explores the TRPC6 overage