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目的:探讨血清中可溶性白细胞介素2受体(sIL-2R)水平、肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平及其在检查丙型肝炎病毒感染中的意义。方法:应用ELISA方法检测42例正常人以及87例丙型肝炎患者血清中sIL-2R、TNF-α和IL-6水平。将病人分为3组:A组:抗HCV-Ab(-),HCVRNA(+)。B组:抗HCVAb(+),HCVRNA(-)。C组:抗HCV-Ab(+),HCV-RNA(+)。结果:3组病人血清中sIL2R、TNF-α和IL-6水平较正常人均明显增高(P<0.01),3组间sIL-2R、TNF-α和IL-6水平比较,除A、C组外,A、B组之间、B、C组之间差异均有统计学意义(P<0.01)。结论:sIL-2R、TNF-α和IL-6水平的检测可作为丙型肝炎诊断的指标之一。
Objective: To investigate the levels of soluble interleukin 2 receptor (sIL-2R), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in serum and their significance in the detection of hepatitis C virus infection significance. Methods: The serum levels of sIL-2R, TNF-α and IL-6 in 42 normal subjects and 87 patients with hepatitis C were detected by ELISA. Patients were divided into 3 groups: Group A: anti-HCV-Ab (-), HCVRNA (+). Group B: anti-HCVAb (+), HCVRNA (-). Group C: anti-HCV-Ab (+), HCV-RNA (+). Results: Serum levels of sIL2R, TNF-α and IL-6 in three groups were significantly higher than those in normal controls (P <0.01). The levels of sIL-2R, TNF-α and IL- In addition, there was significant difference between group A, group B, group B and group C (P <0.01). Conclusion: The detection of sIL-2R, TNF-α and IL-6 levels can be used as one of the indicators of diagnosis of hepatitis C.