人小细胞肺癌的发病率虽不及非小细胞肺癌,但其五年生存率却相对低得多,这两种细胞类型不仅在病理类型上表现不同,在许多其它性质上也表现不同。小细胞肺癌是一种异质性疾病,它由几种形态不同的瘤细胞组成,包括非小细胞肺癌在内;它易早期转移,能在肝、脑和骨髓中繁殖,具有L-Dopa胱羧酶,神经原特异的烯醇化酶(enolase),能合成神经递质和多肽激素蛙皮肽等特性。目前已有关于小细胞肺癌的单克隆抗体的报道,我们采用美国N I H建立的小细胞肺癌细胞株SH-77作免疫原,目前尚未见有关抗该细胞株的单克隆抗体的报道,现将我们制备的三个单抗体及其初步特异性鉴定结果简报如下 Although the incidence of human small cell lung cancer is less than that of non-small cell lung cancer, its five-year survival rate is relatively low. These two cell types not only differ in the pathological type, but also in many other properties. Small cell lung cancer is a heterogeneous disease consisting of several morphologically diverse neoplastic cells, including non-small cell lung cancer; it is susceptible to early metastasis and can multiply in the liver, brain and bone marrow, with L-Dopa cysts. Carboxase, a neuron-specific enolase, can synthesize neurotransmitters and peptide hormones such as proteoglycans. At present, there are reports on monoclonal antibodies against small cell lung cancer. We used the small cell lung cancer cell line SH-77 established by NIH in the United States as an immunogen. At present, there are no reports of monoclonal antibodies against this cell line. Now we will The preparation of the three monoclonal antibodies and their preliminary specific identification results are reported below