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原发性高血压属多基因遗传病,呈遗传易感性与环境因素相结合的发病模式。一般认为人群中血压变异的30％～50％是由遗传因素决定的。EH遗传特点具有易感基因外显不完全性以及基因型和表型不相对应性。通过候选基因的筛选,人们找到一系列与原发性高血压相关的基因。 肾素-血管紧张素系统是血压最重要的调节机制之一,在寻找原发性高血压的易患基因的研究中,各国学者对肾素-血管紧张素系统的相关基因极为重视。肾素基因定位于染色体1q21.3-32.3,由10个外显子和9个内含子组成。近年的一些研究提示肾素基因可能是调节血压的一个基因,然而也有研究提示人群中肾素基因与EH无关;进入90年代,血管紧张素原基因突变与原发性高血压的关系成为研究热点,它定位于第一号染
Essential hypertension is a polygenic disease, genetic susceptibility and environmental factors combined with the incidence pattern. It is generally believed that 30% to 50% of the variation in blood pressure in the population is determined by genetic factors. EH genetic features have the obvious incomplete susceptibility genes and genotype and phenotype incompatibility. Through the screening of candidate genes, people find a series of genes related to essential hypertension. The renin-angiotensin system is one of the most important regulation mechanisms of blood pressure. In the study of predisposition genes of essential hypertension, scholars from all over the world attach great importance to the gene of renin-angiotensin system. The renin gene is located on chromosome 1q21.3-32.3 and consists of 10 exons and 9 introns. In recent years, some studies suggest that the renin gene may be a gene regulating blood pressure, but there are also studies suggest that the renin gene in the crowd has nothing to do with the EH into the 90’s, the relationship between angiotensinogen gene mutations and essential hypertension has become a research hot spot It is located on the first dye