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１０名男性健康志愿者自身交叉单次口服头孢布烯４００ｍｇ或肌注头孢呋辛５００ｍｇ。结果主要动力学参数比较如下：平均Ｃｍａｘ分别为１７．９３±０．９０ｍｇ·Ｌ－１及１８．６６±０．７４ｍｇ·Ｌ－１（Ｐ＞０．０５），平均Ｔｍａｘ１．３８±０．５９及１．０５±０．２６ｈ（Ｐ＜０．０１），表明肌注头孢呋辛比口服头孢布烯吸收略快，但头孢呋辛消除较快，Ｔ１／２仅０．８６±０．２３ｈ，而头孢布烯Ｔ１／２为１．６±０．３７ｈ（Ｐ＜０．００１）。另１０名男性健康志愿者每日口服头孢布烯４００ｍｇ，连服３ｄ，第３ｄ的平均Ｃｍａｘ为１９．２５±０．５９ｍｇ·Ｌ－１，平均Ｔｍａｘ２．３５±０．３４ｈ，与单剂量比较，两参数在统计学上差异非常显著，然而两组间的Ｔ１／２及ＡＵＣ０→１２则无显著性差异
10 male healthy volunteers cross their single oral ceftibuten 400mg or intramuscular cefuroxime 500mg. Results The main kinetic parameters were compared as follows: Mean Cmax were 17.93 ± 0.90 mg · L-1 and 18.66 ± 0.74 mg · L-1, respectively (P> 0.05), with an average Tmax of 1.38 ± 0. 59 and 1.05 ± 0.26h (P <0.01), indicating that intramuscular injection of cefuroxime was slightly faster than oral ceftibuten, but cefuroxime disappeared faster with T1 / 2 of only 0.86 ± 0. 23h while ceftibuten T1 / 2 was 1.6 ± 0.37h (P <0.001). Another 10 male healthy volunteers daily oral ceftibuten 400mg, even serving 3d, the first 3 days of the average Cmax was 19.25 ± 0.59mg · L-1, the average Tmax2.35 ± 0.34h, compared with a single dose , The two parameters were statistically significant differences, however, there was no significant difference between the two groups T1 / 2 and AUC0 → 12