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对35例分化差的肺癌进行了光镜与电镜的观察对比,发现光镜与电镜诊断完全相同者仅10例,占28.6％。光镜诊断的20例低分化鳞癌,在电镜下仅10％为低分化鳞癌,其余60％为腺鳞癌,20％为低分化腺癌,10％为小细胞癌。光镜诊断的5例小细胞癌,电镜诊断者仅1例,其余为类癌2例,低分化腺癌l例,恶性淋巴瘤1例。而电镜诊断的4例类癌,光镜诊断者仅1例,其余则为小细胞癌2例,大细胞癌1例。根据电镜观察,分化差的肺癌以隙鳞癌为最多,占40％。为了给临床提供准确的肺癌组织学类型,对分化差的肺癌进行电镜观察是必要的,也是可行的。
A total of 35 patients with poorly differentiated lung cancer underwent light microscopy and electron microscopy. It was found that only 10 patients (28.6%) had the same diagnosis of light microscopy and electron microscopy. Of the 20 poorly differentiated squamous cell carcinomas diagnosed by light microscopy, only 10% were poorly differentiated squamous cell carcinomas under electron microscope, the remaining 60% were adenosquamous carcinomas, 20% were poorly differentiated adenocarcinomas, and 10% were small cell carcinomas. Light microscopy diagnosis of 5 cases of small cell carcinoma, electron microscopy diagnosis was only 1 case, the rest were 2 cases of carcinoid, 1 case of poorly differentiated adenocarcinoma, 1 case of malignant lymphoma. However, there were 4 cases of carcinoid diagnosed by electron microscopy and only 1 case was diagnosed by light microscopy. The rest were 2 cases of small cell carcinoma and 1 case of large cell carcinoma. According to electron microscopy, poorly differentiated lung cancers accounted for 40% of squamous cell carcinoma. In order to provide clinically accurate histological types of lung cancer, electron microscopic observation of poorly differentiated lung cancer is necessary and feasible.