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Objective: To investigate the expression of thereceptors for vasoactive intestinal peptide (VIP) andsecretin in colon cancer. Methods: This studyvisualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storagephosphor autoradiography. Results: Receptors for VIP and secretin were demonstrated in tumor-free colonand colon tumors. A decrease in affinity of VIPreceptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol). An up-regulation of receptors for secretin was found in colonic liver metastases. Conclusions: VIP and secretin were both expressed on normal colontissues. Binding of VIP decreased while secretinincreased in colonic liver metastasis. A down-regulation of receptors for VIP in colonic liver metastases mayhelpful to understand the migration of colon cancer.
Objective: To investigate the expression of thereceptors for vasoactive intestinal peptide (VIP) andsecretin in colon cancer. Methods: This studyvisualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storagephosphor Autoradiography. Results: Receptors for VIP and secretin were showed in tumor-free colonand colon tumors. A decrease in affinity of VIPreceptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol ). An up-regulation of receptors for secretin was found in colonic liver metastases. Conclusions: VIP and secretin were both expressed on normal colontissues. Binding of VIP decreased while secretinincreased in colonic liver metastasis. A down-regulation of receptors for VIP in colonic Liver metastases may helpful to understand the migration of colon cancer.