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关于色素性视网膜炎可能存在免疫机制改变的研究很少。Fessel[1966]第一次描述了10例色素性视网膜炎(RP)有6例存在类风湿因子和I_gM升高。但Spalton等在1例RP中仅发现5例有这种免疫球蛋白的升高,2例有类风湿因子,其它病人的免疫球白及C_3均在正常水平。对色素上皮及杆细胞外段抗原的免疫反应的存在,可以造成视网膜变性过程中视网膜水肿的炎性反应及血管渗透性增高。一些学者认为可能存在循环性免疫复合体(CIC)这种CIC可能形成并储蓄在一个局部水平,在原地储蓄的CIC将产生一种炎症,在刺激组织损伤中,CIC起了很大作用。虽然CIC不一定参与了病源活动,但他们常常反映了免疫系统的改变。粘附在B细胞或T细胞的CIC影响和决定了免疫反应所必然的细胞与
Little research has been done on the possible changes in the immunological mechanism of retinitis pigmentosa. Fessel [1966] for the first time described the presence of rheumatoid factor and elevated I_gM in 6 of 10 retinitis pigmentosa (RP). However, Spalton et al found that in only 1 patient RP, only 5 patients had elevated immunoglobulin, 2 patients had rheumatoid factor, and other patients had normal immunoglobulin and C_3. The presence of an immune response to pigment epithelium and rod extracellular antigen can result in an inflammatory response to retinal edema and increased vascular permeability during retinal degeneration. Some scholars believe that there may be a circulating immune complex (CIC) that CIC may form and save at a local level, CIC will have an in-place accumulation of inflammation, in stimulating tissue damage, CIC played a significant role. Although CICs are not necessarily involved in pathogenic activity, they often reflect changes in the immune system. CICs that adhere to B cells or T cells influence and determine the cells necessary for the immune response