AbcA1相关论文
目的:丙戊酸(Valproic acid,VPA)是一种广谱抗癫痫药物,用于癫痫发作的单药治疗和辅助治疗。VPA在监测其血药浓度水平时,毒性作用不......
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目的年龄相关性黄斑变性(AMD)是老年人致盲的主要原因之一,其发生与机体血清维生素和类胡萝卜素降低有关。胆固醇代谢基因参与这些营......
目的 探讨ATP结合盒亚家族A成员1(ABCA1)对人胃癌侵袭、迁移及上皮间质转化(EMT)的影响及其机制。方法 基于网络数据库进行生物信息学......
目的 研究三七丹参片对高血脂症小鼠的降脂作用及调控机制.方法 将40只C57BL/6小鼠随机分为正常组、模型组及三七丹参片高(1.35 g/......
ATP结合盒转运体A1(ABCA1)在细胞内胆固醇流出中起着重要作用,增加它的表达可促进细胞内胆固醇流出,降低动脉粥样硬化风险.ABCA1的......
目的:心脑血管疾病是危害人类健康的全球性疾病,动脉粥样硬化(Atherosclerosis,AS)是其最主要的病理学基础。高密度脂蛋白(High densi......
目的 观察右归丸含药血清对THP-1源性泡沫细胞内SREBP-1c和ABCA1因子表达的影响,以探讨右归丸对泡沫细胞内胆固醇代谢的影响及机制......
食管癌(EC)是一种常见的恶性肿瘤,根据2018年全球癌症统计,食管癌的发病率在所有恶性肿瘤中排名第七,死亡率在第六位。与欧美国家不......
Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and mouse mastitis
Glycyrrhizin, a triterpene glycoside isolated from licorice root, has been known to exhibit anti-inflammatory activities......
Leukocyte ABC-transporter A1 and LDL receptor play independent roles in atherosclerosis: the potenti
Background: LDL receptor (LDLr) and ABC-transporter A1 (ABCA1) are two distinct players in cellular cholesterol homeosta......
目的:观察apelin-13 是否通过影响ABCA1 蛋白水平从而调节Aβ 代谢。方法:①Western blot 检测PC-12细胞血管紧张素受体AT1 相关的受......
目的:在人视网膜色素上皮细胞(retinal pigmented epithelial,RPE)中,用淀粉样蛋白β(amyloid β,Aβ)1-40 诱导细胞的炎症反应后,......
目的:在人视网膜色素上皮细胞(retinal pigmented epithelial,RPE)中,用淀粉样蛋白β(amyloid β,Aβ) 1-40诱导细胞的炎症和衰老反......
ATP-Binding Cassette Transporter A1(ABCA1)polymorphisms are associated with various diseases.Previous studies have found......
研究目的:揭示巨噬细胞TLR信号活化对miR-33表达的影响及调控机制,并阐明miR-33对巨噬细胞炎症应答的调控作用及其分子机制。材料和......
目的:GPR120 是脂肪酸受体家族成员,在巨噬细胞中高表达,已有研究表明:在巨噬细胞中,GPR120 激活具有抗炎和胰岛素增敏的作用,然而GP......
Leukocyte ABC-transporter A1 and LDL Receptor Play Independent Roles in Atherosclerosis :the Potenti
Objective The present study aims to investigate whether LDL receptor (LDLR) deficiency influences the atheroprotective e......
DNA Topoisomerase Ⅱ Inhibitors Induce Macrophage ABCA1 Expression and Cholesterol Efflux: New Functi
ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux and thereby inhibits lipid-laden macrophage/f......
Biological characteristics of foam cell formation in smooth muscle cells derived from bone marrow st
Bone marrow mesenchyrnal stem cells (BMSC) can differentiate into diverse cell types,including adipogenic,osteogenic,cho......
Curcumin preserves cognitive function and improve serum HDL in Chronic cerebral hypoperfusion aging-
Objective Chronic cerebral hypopeffusion is believed to be a critical factor on the occurrence of AD and VaD for which t......
苯并噻唑类化合物5242331是通过高通量筛选得到的小分子ABCA1和SR-B1双重基因上调表达剂,具有较好的抗动脉粥样硬化作用.以4正丁基......
目的:考察济阴颗粒对雌性冠心病大鼠脂代谢通路因子小窝蛋白1(caveolin-1,Cav-1)、低密度脂蛋白受体(low density lipoprotein rec......
Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f,which displays pot......
Sepsis is a systemic inflammatory response syndrome with high mortality.It has been reported that brefeldin A-inhibited ......
目的:探讨三磷酸腺苷结合盒转运子A1(ATP binding cassette transporter 1,ABCA1)基因1587单核苷酸多态性(single nucleotide poly......
目的探讨ABCA1基因R219K多态性在汉族人群中的分布,分析其与血脂及冠心病的关系。方法采用聚合酶链反应-限制性片段长度多态性(pol......
目的探讨晚期氧化蛋白产物对THP-1巨噬细胞源性泡沫细胞三磷酸腺苷结合盒转运体A1表达及胆固醇流出的影响。方法用160nmol/L的佛波......
Purpose: Recently, three large genome-wide association studies have identified multiple variants associated with pri......
过量胆固醇蓄积和炎症激活是动脉粥样硬化(AS)发展过程中的两个主要病理过程。据研究报道三磷酸腺苷结合盒转运体(ABCA1)能转运细......
动脉粥样硬化是心血管疾病的主要病理基础,细胞内胆固醇蓄积引起的泡沫细胞形成是导致动脉粥样硬化发展的重要因素。三磷酸腺苷结......
目的micro RNA-33可以抑制ABCA1,增加细胞蓄脂,促进动脉粥样硬化斑块的形成。环状RNA可作为mi RNA海绵抑制mi-RNA的表达,hsa_circ_......
目的:研究ATP结合盒转运蛋白A1(adenosine triphosphate-binding cassette transporter A1,ABCA1)基因rs1800976、rs4149313和rs22......
目的:动脉血管内皮下巨噬细胞对胆固醇酯特别是氧化低密度脂蛋白(ox-LDL)摄取和流出的不平衡被认为是导致泡沫细胞形成及早期动脉......
Myristica fragrans is a traditional herbal medicine and has been shown to alleviate the develop-ment of atherosclerosis.......
目的:观察小陷胸汤对RAW264.7源泡沫细胞中ABCA1、ABCG1蛋白表达和胆固醇流出的影响,探讨小陷胸汤防治动脉粥样硬化的作用机理。方......
三磷酸腺苷结合盒转运体A1 (ATP binding cassette transporter A1,ABCA1)是一种膜整合蛋白质,在真核细胞中分布广泛,具有多种生物......
【研究背景与目的】动脉粥样硬化(Atherosclerosis,As)是一种以脂质在动脉血管壁沉积为特征的多因素疾病,巨噬细胞源性泡沫细胞形......
SETD2是哺乳动物细胞中主要催化组蛋白H3K36三甲基化(H3K36me3)修饰的甲基转移酶。H3K36me3修饰是从酵母到哺乳动物中最保守的表观......
目的探讨慢性脑血流灌注不足对老龄大鼠海马组织CA1区ABCA1的表达及血清中总胆固醇(Total cholesterod,TC)和高密度脂蛋白(High de......
目的观察表没食子儿茶素没食子酸酯(EGCG)对脂多糖(LPS)处理的THP-1源性泡沫细胞胆固醇流出及其ABCA1活性的影响,并探讨其机制。方......
目的:观察化瘀祛痰方药及其拆方对THP-1源性泡沫细胞腺苷三磷酸结合盒转运体A1(ABCA1)、CD36表达的影响,探讨该方药的作用机制,并......
妊娠期疾病一般认为是体内外多种因素共同参与,造成母体及胎儿生理机能出现异常,引起的一系列相关疾病,如早产、妊娠期糖尿病、妊......
目的探讨ABCA1基因多态性及其与肥胖的交互作用在低HDL-C血症的作用。方法按照年龄和性别匹配方法,从5692名成年哈萨克族人中随机......
三磷酸腺苷结合盒转运体A1(ABCA1)是体内胆固醇逆向转运的关键环节.对氧磷是广泛使用的有机磷农药的活性代谢产物.研究发现,对氧磷......