Deoxycytidine相关论文
Dietary exposure to di-isobutyl phthalate increases urinary 5-methyl-2′-deoxycytidine level and affe
Phthalates are a large family of ubiquitous environmental pollutants suspected of being endocrine disruptors. Epidemiolo......
使用 IDU 治疗角膜疱疹已有许多作者认为是有疗效的,而 IDC(5-iodo-2′-deoxycytidine)比 IDU 更较稳定且溶解度较高,它的作用也是......
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epi
In our previous studies, significant hypermethylation of the sirtuin 1(SIRT1) gene and demethylation of the b-amyloid pr......
The non-classical HLA class I antigen HLA-G is an immune modulator which inhibits the functions of T cells, NK cells, an......
Objective To investigate the effects and related mechanism of 5-aza-2’-deoxycytidine(Aza)on endothelial function in Hyp......
Objective.To investigate the frequency of p16a nd p15gene methylation in multiple myeloma (MM),and its relationship with......
Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon
AIM:To investigate the effects of DNA methylation on theexpression of tumor suppressor genes and proto-oncogenein human......
甲基化紊乱与胃癌的发生有关,近年来甲基化已成为肿瘤研究的热点。目的:探讨在DNA甲基转移酶抑制剂5-氮脱氧胞苷(5-aza-2’-deoxyc......
目的 观察DNA甲基化和组蛋白乙酰化对人结肠癌细胞系癌相关基因的表达和细胞周期的影响。方法 培养 2种结肠癌细胞系SW 1 1 1 6......
Downregulation of retinoic acid receptor-β_z expression is linked to aberrant methylation in esophag
AIM.To study the role of hypermethylation in the loss ofretinoic acid receptor β_2(RARβ_2) in esophageal squamouscell......
Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressi
The aim of this study is to assess the effects of DNA methylation and historic acetylation, alone or in combination, on ......
Hepatocellular carcinoma(HCC)is one of the mostcommon human malignancies worldwide, and isclosely associated with infec......
The laser photochemistry and photosensitization of DNA bases were carried out by using a nanosecond kinetic spectroscopy......
The effect of 5-aza-CR and 5-aza-2’-deoxycytidine(5-aza-CdR)on cell differentiation and DNA methylation of HL-60 cells ......
AIM: To screen out the differentially methylated DNA sequences between gastric primary tumor and metastatic lymph nodes,......
Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in ga
AIM: To identify the methylation of secreted frizzled-related protein 1 (SFRP1) in gastric cancer and to investigate the......
目的研究细胞有丝分裂前期检查点(checkpoint with forkhead associated and ring finger,CHFR)在人肝癌细胞株HepG2中的表达,以及......
Objective: To explore the usefulness of long distance reverse transcript combining linear amplification (LD-RTPCR) in la......
Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatog
AIM: To establish a high pressure liquid chromatography (HPLC) method for determination of the concentration of gemcita......
Gene induction and apoptosis in human hepatocellular carcinoma cells SMMC-7721 exposed to 5-aza-2′-d
Background Aberrant DNA methylation plays a key role in human carcinogenesis.5-aza-2’-deoxycytidine inhibitsDNA methyl......
Investigation of transcriptional gene silencing and mechanism induced by shRNAs targeted to RUNX3 in
AIM:To investigate transcriptional gene silencing induced by short hairpin RNAs (shRNAs) that target gene prompter regio......
Objective:hMLH1 protein serves to detect the DNA damage caused by cisplatin(DDP) and destroys the cell.The absence of hM......
AIM: To understand CD133 promoter hypermethyl-ation and expression in 32 colorectal cancer cell lines. METHODS: Nucleic ......
ESR STUDIES OF SPIN-TRAPPED RADICALS IN GAMMA-IRRADIATED POLYCRYSTALLINE PYRIMIDINE NUCLEOSIDES——CYT
Room-temperature free radicals produced in four gamma-irradiated polycrystalline pyrimidine nucleosides (cytidine, deox......
AIM: To clarify the role of high in normal-1 (HIN-1) gene promoter methylation during gastric cancer development. METHOD......
AIM:To identify methylation profile and novel tumor marker of extrahepatic cholangiocarcinoma(CCA)with high throughout m......
Objective: To investigate the effects of 5-Aza-2’-deoxycytidine (5-Aza-Cdr) and trichostatin A (TSA) combined with p53-......
AIM:To investigate the methylation status of secreted protein acidic and rich in cysteine(SPARC) in human hepatocellular......
目的胶质瘤的化疗一直都是研究热点,近来有研究表明甲基化与胶质瘤的发生和发展关系密切,本研究的目的是探讨去甲基化试剂5-氮杂-2......
为探讨结肠癌细胞SW480和HT-29中LHX6基因启动子区CpG岛的甲基化状态,分析去甲基化与结肠癌细胞增殖的关系,用甲基化特异性PCR对SW......
目的:探讨DNA甲基化抑制剂5-氮杂胞苷(5-Aza-2’-deoxycytidine,5-Aza-CdR)在增强人非小细胞肺癌(non-smallcell lung cancer,NSCL......
Objective:To explore effect of 5-AZn-2’-deoxycytidine on proliferation of human lung adenocarcinoma cell line A549 in v......
AIM: To investigate the effect of 5-Aza-2’-deoxycytidine(5-Aza-CdR),a DNA methyltransferase(DNMT) inhibitor,on the grow......
AIM: To examine the methylation levels of interleukin-1 receptor-associated kinase 3(IRAK3) and GLOXD1 and their potenti......
,Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromato
AIM: To establish a high pressure liquid chromatography (HPLC) method for determination of the concentration of gemcitab......
[目的]探讨暴露于DNA甲基化抑制剂5-Aza-2’-deoxycytidine(5-Aza-CdR)对新生SD大鼠生长发育和成年精子发生的影响。[方法]新生大......
目的 观察主要组织相容性复合体Ⅰ类分子A(MICA)在HepG2与L02细胞株中表达的差异及脱氧氮杂胞苷(5-aza-dC)对HepG2细胞株MICA表达......
目的 比较不同肝癌细胞株对5-氮杂-2’-脱氧胞苷(5-aza-dC)的敏感性,探讨肝癌细胞对5-aza-dC的敏感性是否与细胞总DNA甲基化水平有......
为了探讨卡培他滨联合多西紫杉醇（DTX）治疗蒽环类耐药的转移性乳腺癌的疗效及不良反应，将61例确诊蒽环类耐药的转移性乳腺癌分为两组，......
目的:观察泽菲(盐酸吉西他滨,gemcitabine)联合奥沙利铂(oxaliplatin,L-OHP)和地塞米松(DXM)对复发性或难治性进展型非霍奇金淋巴......
为了探讨卡培他滨和多西紫杉醇联合方案治疗转移性乳腺癌的疗效及不良反应，29例转移性乳腺癌患者接受卡培他滨和多西紫杉联合方案化......
为了观察吉西他滨（GEM）联合卡培他滨治疗蒽环类和（或）紫杉类耐药性晚期乳腺癌的疗效和毒副反应,2003-01-2006-03应用GEM联合卡培他滨治......
目的：研究5-氮-2＇-脱氧胞苷（5-Aza—CdR）和曲古菌素A（TSA）对乳腺癌MDA-MB-435S细胞增殖及抑癌基因maspin表达的影响。方法：用特异性甲基转......
目的：研究5-氮杂2′-脱氧胞苷（5-Aza-CdR）对MCF-7乳腺癌细胞株生长周期及凋亡的影响，探讨其临床治疗乳腺癌的可能性。方法：分别使用浓度......
目的：研究甲基化酶抑制剂5-杂氮脱氧胞苷（5-aza-2‘-deoxycytidine，ADC）对人绒毛膜上皮癌细胞株JEG-3细胞的生物学作用，观察JEG-3细胞H1......
目的观察去甲基化制剂5-氮杂-2′-脱氧胞苷（5-Aza-CdR）对体外培养的卵巢癌细胞CAOV3p16基因启动子区甲基化状态及表达的影响,探讨卵......
目的研究甲基化抑制剂5-氮-2’-脱氧胞苷（5-Aza-dc）对T24膀胱癌细胞生长的抑制作用及对RUNX3基因的转录调节作用。方法不同浓度5-Aza......
目的探讨5-氮杂-2＇-脱氧胞苷（5-Aza）联合临床化疗药物紫杉醇与氟尿嘧啶对于胃癌裸鼠移植瘤生长的抑制作用和抑癌基因RUNX3 mRNA以及肿......
