STEREOSELECTIVITY相关论文
Aim: To investigate the stereoselective metabolism of phencynonate.Methods: Phencynonate enantiomers were isocratically ......
Objective To investigate the in vitro stereoselective metabolism of phencynonate as a novel anticholinergic chiral drug.......
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Aim: To study the stereoselective metabolism of phencynonate isomers and their molecular docking with the mACh receptor.......
Reaction mechanisms of [2+2] cycloaddition of ketene and ketimine catalyzed by N-heterocyclic carben
N-heterocyclic carbenes (NHCs) have attracted great attention because of their high and special activity[1].Recently,NHC......
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The precisely controlled polymerization of diene and styrene by using rare-earth metal catalysts will be reported.The pi......
N-heterocyclic carbene catalyzed enantioselective cascade reaction of enals has been developed with significant progress......
Chondroitin sulfate E (CS-E) is a linear sulfated polysaccharide composed of repeating dimeric units GlcA-β(1 →3)-GalN......
Allenes are a class of unique compounds with two π-orbitals perpendicular to each other.For various substituted allenes......
Engineered P450s can catalyze the non-natural reactions such as carbine transfer reaction with high efficiency and selec......
Cyclopropane and its derivatives play an important role in the total synthesis of complex compounds, natural products, a......
Mechanism and Origin of Stereoselectivity of Pd-Catalyzed Cascade Annulation of Aryl Halide,Alkene,a
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Azobenzene(AB)is one of the most widely studied optical switching molecules.In recent years,photoswitchable macrocyc......
Recycling of carbon dioxide into value-added organic molecules and materials has received widespread attention among......
It is well known that the substrate activation strategy with noncovalent interactions has been widely used in the fi......
In continuation of our work on the interaction of 1,2-diphenylcyclopropenes with stabilized azomethine-ylides genera......
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Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral adminis
AIM: To study the stereoselectivity of phase Ⅱglucuronidation metabolism of side-chain propranolol in Chinese Hah popul......
Access to Stereodefined Multifunctionalized β,γ-Unsaturated Ketones via Chemo-, Regio-and Diastereos
Stereodefined β,γ-unsaturated carbonyl compounds are important yet synthetically challenging units in natural products......
Stereoselective isomerization of α-alkyl styrenes is accomplished using a new iron catalyst supported by phosphine-pyri......
首次报道了甲基咪唑型离子液体在进行6-0-乙酰基-2,3,4-O-三-苄基-甘露糖三氯乙酰亚胺酯供体与离子液体载体的糖基化过程中的β导......
Promotion Mechanism of H2O for Stereoselectivity in Pd(Ⅱ)-catalyzed C—H Arylation of Diarylphosphina
On the basis of a series of control experiments and nuclear magnetic resonance analyses,it is discovered that Boc-protec......
Aim: To investigate the stereoselectivity in human metabolic 3-reduction oftibolone. Methods: Twenty healthy Chinese fem......
,Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in v
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Reductions of carbonyl groups catalyzed by oxidoreduc-tases are involved in all biological processes and are often a cla......
Highly efficient synthesis of (R)-1,3-butanediol via anti-Prelog reduction of 4-hydroxy-2-butanone w
(R)-1,3-butanediol is an important pharmaceutical intermediate, and the synthesis of (R)-1,3-butanediol using green biol......
Analysis of chiral non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac bindi
The protein binding of non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac with human serum albu......
双羰基还原酶(diketoreductase)选择性催化β,δ-二羰基酯底物还原生成相应的双羟基产物,其对映体过量(ee)和非对映体过量(de)均大......
A Facile and Highly Stereoselective Reductive Debromination of Anhydro-6- (R)-Hydroxyethyl- 6-Bromop
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Effect of Electronic Structures of Enantiomers of Ruthenium(II) Polypyridyl Complexes on DNA Binding
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Chiral Sulfinamide-Olefin Ligands: Switchable Selectivity in Rhodium-Catalyzed Asymmetric 1,2-Additi
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
High Trans-1,4 (Co)Polymerization of β-Myrcene and Isoprene with an Iminophosphonamide Lanthanum Cat
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Stereoselective Ring-opening Polymerization of rac-Lactide by Bulky Chiral and Achiral N-heterocycli
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Stereoselective urinary excretion of S-(-)- and R-(+)-propranolol glucuronide following oral adminis
AIM: To study the stereoselectivity of phase Ⅱglucuronidation metabolism of side-chain propranolol in Chinese Hah popul......
A Facile and Highly Stereoselective Reductive Debromination of Anhydro-6- (R)-Hydroxyethyl- 6-Bromop
Reductive debromination of anhydro-6-(R)-hydroxyethyl-6-bromopenicillin 7 by zinc in ammonium acetate gave 9 in 81% yiel......
The effects of two different amino acid catalysts on the stereoselectivities in the direct Mannich reactions of cyclohex......
A series of trans-3-chloro-β-lactams was synthesized stereospecifically from imines and chloroacetyl chloride or a mixt......
有机反应的立体选择性和有机化合物的立体异构现象不仅在有机化学,在药物科学和生命科学等相关学科领域中也是具有极其重要意义的......
应用具有刚性结构的三环癸二烯酮，经高度立体选择性地引入官能团及逆第尔斯－阿尔德反庆，合成了文题化合物（Ｆｒｏｎｔａｌｉｎ），总产率约２４．４％。......
以具有刚性结构的三环癸二烯酮为原料，立体专一性引入官能团，经逆第尔斯－阿尔德反应，合成了文题化合物，总产率３５．２％。......
分别用水杨醛铜、β-二酮-铜和希夫碱-铜络合物为催化剂进行β-（-）-蒎烯与重氮乙酸酯的不对称环丙烷化反应，研究了催化剂结构与反应立......
STEREOSELECTIVE EFFECT OF PROPRANOLOL ON ANTIPYRINE METABOLISM AND ISOPRENALINEINDUCED TACHYCARDIA I
【正】 The effects of l-, d- and dl-propranolol on antipyrine metabolism and isoprenaline-induced tachycardia were studi......
目的:研究酮洛芬前体药物(酮洛芬甲酯、乙酯和异丙酯)经离体SD大鼠皮肤渗透代谢的立体选择性,为利用前体药物方法促进透皮吸收提供......
报道以价廉易得的Ｄ－（＋）－木糖为手性源，经５步反应，立体选择性合成１９－失碳－１α，２５－二羟基维生素Ｄ３Ａ环关键中间体（２Ｓ，４Ｓ）－１，５－二氯－２，４－戊二醇（５）的方法，该方法具有收率高，原料和试......
