cytochromeP450相关论文
Pyrrolizidine alkaloids(PAs)are the most common phytotoxins with documented human hepatotoxicity.PAs require metabolic a......
P450 fatty acid decarboxylase OleT from Staphylococcus aureus (OleTsA) is a novel cytochrome P450 enzyme that catalyzes ......
Taxol(Paclitaxel),an important anticancer drug,is derived at very low yields from Taxus(yew)species that grow very slowl......
Synthesis and anti-hepatocellular carcinoma activity of novel O2-vinyl diazeniumdiolate-based nitric
Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) ha......
A hepatoprotection study of Radix Bupleuri on acetaminophen-induced liver injury based on CYP450 inh
We investigated the potential hepatoprotective effect of Radix Bupleuri (RB) by inducing acute liver injury (ALI) in an ......
Low herbicide dose selection results in P450-based enhanced herbicide metabolism resistance in Loliu
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N-Nitrosonornicotine(NNN)is considered to be one of the most carcinogenic compounds of the four conventionally measured ......
Induction of cytochrome P450 genes is both gene and insecticide dependent in the red flour beetle (T
One remarkable feature of insect cytochrome P450 genes is that the transcription level is induced by foreignchemicals or......
Identification and characterization of two cytochrome P450 genes potentially involved in fenpropathr
The carmine spider mite,Tetranychus cinnabarinus is one of the most serious mite pests on crops.It is capable to rapidly......
Cytochrome P450 monooxygenses have been proven to be associated with high resistance in Bemisia tabaci B(Middle East-Min......
Cytochrome P450 monooxygenases of fungi are widely distributed hemo-proteins involved in various steps of the biosynthes......
Objective: To study the effects of gatifloxacin on hepatic microsome cytochrornes P450.Methods: The male Wistar rats wer......
Hypoglycemic effects of columbin and its influences on cytochrome P450 enzyme in experimental type 2
OBJECTIVE To study the hypoglycemic effects of columbin and its effects on catalytic activities as well as gene expressi......
CYP1A1 exon 7 and GSTM1 polymorphism and lung cancer susceptibility of Han population in Inner Mongo
OBJECTIVE To estimate the relative risk for lung cancer associated with genetic polymorphism of the exon7 mutation (Ile/......
20-hydroxyeicosatetraenoic acid(20-HETE)as an important metabolism of arachidonic acid(AA).Since it was discovered,it wa......
Aim: To investigate the stereoselective metabolism of phencynonate.Methods: Phencynonate enantiomers were isocratically ......
Objective To investigate the in vitro stereoselective metabolism of phencynonate as a novel anticholinergic chiral drug.......
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Polycystic ovary syndrome(PCOS)is a common endocrine disorder and a major cause of anovulatory sterility in women at rep......
Interaction of CYP2C8, EPHX2, and CYP4A11 variants, CYP plasma metabolite levels, and ischemic strok
Aim: To better understand the relationship between the interaction of rs17110453,rs751141,and rs9333025,plasma levels of......
Chemical of herbal products may cause unexpected toxicity effect by the potential for alteration of the activity of huma......
Cytochrome (CYP) 4A11 genetic polymorphisms increase susceptibility to ischemic stroke and associate
Objective: CYP4A11 and CYP4F2 are responsible for metabolizing arachidonic acid (AA) into 20-hydroxyeicosatetraenoic aci......
Stroke is the second leading cause of death in developed countries.Ischemic stroke (IS), the most common type of stroke,......
Aim: To study the stereoselective metabolism of phencynonate isomers and their molecular docking with the mACh receptor.......
In order to simultaneously determine in vivo cytochromes P450 1A2 (CYP1A2) and 3A (CYP3A) activity in rat, a simple rapi......
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Objective:To study the effects of the water extract of Angelica sinensis (Oliv.) Diels.and Codonopsis pilosula (Franch.)......
Coumarin Type of Miconazole Analogues:Biological Evaluation and Supramolecular Intreraction with Cyt
A novel series of coumarin type of Miconazole analogues were designed,synthesized and characterized by IR,NMR,MS and HRM......
Cytochrome P450(CYP)17A1 is a dual-function monooxygenase with a critical role in the synthesis or many human steroid ho......
Molecular Basis of the Recognition of Arachidonic Acid by Cytochrome P450 2E1 Along Major Access Tun
Cytochrome P450 2E1 is widely known for its ability to oxidize both low molecular weight xenobiotics and endogenous fatt......
In sil Prediction of Cytochrome P450 Inhibition and Inhibitory Promiscuity: Towards an Understanding
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Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases.Rutaecarpine has be......
Mutationsingenesencodingkeyplayersinoncogenicsignalingpathwaystriggerspecificdownstreamgeneexpressionprofilesintherespec......
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Cytochrome P450(P450)enzymes are the major catalysts involved in the metabolism of drugs,steroids,chemical carcinoge......
Expression of TaCYP78A3, genes encoding Cytochrome P450 78A3 proteins in wheat (Triticum aestivum L.
Several studies have described quantitative trait loci (QTL) for seed size in wheat, but the relevant genes and mole......
Vascular adventitial remodeling is an important pathologic process in multiple vascular diseases.Reactive oxygen spe......
Effect of RNA interference of CYP6B47 on detoxification of plant allelochemicals by Spodoptera litur
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A CYP450 Oligonucleotide Microarray for Detecting Genetic Variations of CYP2C9,CYP2C19,CYP2D6 and CY
The cytochrome P450 enzymes play a critical role in the metabolism of many commonly prescribed drugs.Among them,the ......
Dual-Functional Small Molecule Facilitated P450BM3 Peroxygenase for Catalytic Oxidation of Non-Nativ
Cytochrome P450 monooxygenase are a superfamily of heme enzyme with a cysteine as axial ligand,which catalyze the mo......
使药产生代射变化的酶，也作为细胞色素 P450s 知道，是负责使超过 90% 临床的药产生代射变化的血红素的一个总科。细胞色素 P450 2D6 ......
目的检测广东地区正常人群和鼻咽癌患者中细胞色素P450酶系CYP2F1基因的多态性，并分析该基因遗传多态性与鼻咽癌易感性的关联。方法......
目的:通过3-溴丙酮酸(3-BrPA)处理秀丽隐杆线虫(Caenorhabditis elegans),观察3-BrPA对线虫的毒性和生存周期的影响.通过秀丽隐杆......
细胞色素P450（CYP）是混合功能氧化酶超家族中含有血红素的膜蛋白，可对各种外源性物质包括药物、致癌物和其他化合物及内源性底物（如类......
五味子主要成分为五味子乙素、五味子酯甲、五味子甲素、五味子酯乙、五味子醇乙等,可通过影响CYP 450、P-糖蛋白(p-gp)、孕烷X受......
目的 阐明结膜吸吮线虫(Thelazia callipaeda)基因组的序列特征.方法 采用GeneMark、GeneID和GeMoMa软件对结膜吸吮线虫基因组组装......
感染及炎症相关性疾病是目前威胁人类健康的重要病种，若未及时控制，患者将出现一系列并发症，如脓毒症、炎性因子"风暴"等，甚至导致死亡......
目的 观察细胞色素450 1A1(CYP1A1)的基因多态性和多西他赛联合卡培他滨治疗转移性乳腺癌疗效的相关性.方法 入选69例接受多西他赛......
An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 e
An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of ......
